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Volume 154, Issue 2
1 \5 t! s5 e, oOn the cover: In this issue of Cell, Terasaki et al. (pp. 285–296)
# u: ~, Y' u8 s/ `5 c. [explain how parallel sheets of endoplasmic reticulum are connected. The / |& b( V! M) h* i
existence of these sheet stacks and their function in synthesis of membrane and
4 o n3 o7 N; @" y4 o# F, c( Usecreted proteins has been known for more than 60 years. Three-dimensional
+ K3 f- O4 O, {( N7 G5 H( Lreconstructions from serial section electron micrographs from mouse salivary
, F! I: \% T8 @1 e% a% Cgland show that the sheets are connected by twisted membrane surfaces with 8 ~8 y) c' g: P1 X/ f1 `
helical edges. The overall structure resembles a parking garage, in which the
' ]3 j; f6 k D- f, }different levels are connected by helicoidal ramps. Theoretical calculations 9 p; ?8 ~1 t% S
show that this structure minimizes the elastic energy of sheet edges and ; F9 F3 z3 L( ?% p0 [; F
surfaces and allows dense packing of this organelle in the restricted space of a
0 _6 G# a" K i7 }& d! pcell.! y# Z1 O% Z8 A
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