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False-colored scanning electron micrograph of erythrocytes
0 l7 Q. f- c; B4 l+ o(diameter ~7 micrometers). Sickle cell disease results from an1 s( \4 j* C! {( T1 x5 u
inherited defect of adult hemoglobin, the oxygen-carrying
$ ] h* B M1 R. o3 qmetalloprotein constituent of erythrocytes. Common genetic variation
5 \. t9 W" B- k! i0 e- @associated with sickle cell disease severity modulates an adult-stage
9 N& `# ]( v0 _- Y: gerythroid enhancer element of the BCL11A gene. Disruption of this& b: G3 t4 A d! A/ }
element could ameliorate the disease by reestablishing expression! ?0 c0 s) S0 j9 I: S4 t
of fetal hemoglobin. See pages 206 and 253.$ {. y& K2 ]1 r
) V4 m. I+ |1 U4 r6 J
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发表于 2013-10-12 08:20
发表于 2013-10-12 08:41
