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False-colored scanning electron micrograph of erythrocytes1 o0 B6 \& J: w/ z' A
(diameter ~7 micrometers). Sickle cell disease results from an. L* p6 l% F$ Z* E. p2 F* m
inherited defect of adult hemoglobin, the oxygen-carrying
# {' _% \' J$ _# G' J! b, Ymetalloprotein constituent of erythrocytes. Common genetic variation
- i- \7 O+ M9 N( cassociated with sickle cell disease severity modulates an adult-stage
' i" q; N% o* b* J! g( U' Serythroid enhancer element of the BCL11A gene. Disruption of this
) `0 L) n* Z4 @; R: Gelement could ameliorate the disease by reestablishing expression/ y. @: x, B6 Y& s1 M- `" {
of fetal hemoglobin. See pages 206 and 253.. r, W* H7 X% N% P
$ N1 W0 I4 t/ {( h
& {' d# ] n. w% ~4 d
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