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False-colored scanning electron micrograph of erythrocytes
+ T$ d O2 M/ \% F7 a- n(diameter ~7 micrometers). Sickle cell disease results from an/ ~5 t }% R# `/ _# M8 E
inherited defect of adult hemoglobin, the oxygen-carrying- ~, R7 U7 A, A. p& t
metalloprotein constituent of erythrocytes. Common genetic variation
- l P9 x" O/ e- _( Lassociated with sickle cell disease severity modulates an adult-stage6 j2 J- g5 r' V% h- m* O
erythroid enhancer element of the BCL11A gene. Disruption of this
3 f% L. Y/ b4 r" I5 O$ Helement could ameliorate the disease by reestablishing expression% i3 D: _9 M5 l$ B$ I; Z
of fetal hemoglobin. See pages 206 and 253.
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' n6 g9 X" _4 V' ?9 V$ L! V+ N$ m/ L0 x, ?$ w* c }9 O* `
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发表于 2013-10-12 08:20
发表于 2013-10-12 08:41
