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False-colored scanning electron micrograph of erythrocytes
: t1 Z" s4 h! \# i) {(diameter ~7 micrometers). Sickle cell disease results from an1 z/ U3 {. l) X* u# A9 F1 U& `
inherited defect of adult hemoglobin, the oxygen-carrying
8 t+ S' C. |9 mmetalloprotein constituent of erythrocytes. Common genetic variation5 {; h, I! R; C& i7 h8 r; t8 n$ j
associated with sickle cell disease severity modulates an adult-stage
6 M8 o1 ^& o1 b4 ~0 werythroid enhancer element of the BCL11A gene. Disruption of this2 {" K- {+ z- v7 z& m+ u, o
element could ameliorate the disease by reestablishing expression
( m6 h. b' L+ pof fetal hemoglobin. See pages 206 and 253.
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发表于 2013-10-12 08:20
发表于 2013-10-12 08:41
