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False-colored scanning electron micrograph of erythrocytes
4 b- A7 l3 @ B(diameter ~7 micrometers). Sickle cell disease results from an
! \- N7 w2 l4 z3 Yinherited defect of adult hemoglobin, the oxygen-carrying9 f2 r, L% z, N8 N; s+ i
metalloprotein constituent of erythrocytes. Common genetic variation
Y- j9 \! b" w/ D( Gassociated with sickle cell disease severity modulates an adult-stage; ]+ K1 v2 j1 E. S3 O5 E: t
erythroid enhancer element of the BCL11A gene. Disruption of this
5 W8 f! Q2 d- o! J9 Z4 c6 ]element could ameliorate the disease by reestablishing expression
2 `3 f/ }5 q7 ?+ T5 M3 uof fetal hemoglobin. See pages 206 and 253.% l9 t7 y3 R# ^1 E6 Z5 Q' @
1 R3 r% q E. o% ^
0 x5 u' k. M# p7 Y# x7 f2 l4 J回复有免费下载链接$ {7 {$ t3 v2 e- z2 {
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发表于 2013-10-12 08:20
发表于 2013-10-12 08:41
