2013年12月12日 Nature

nero1981

* H, R+ L6 M6 B' k( PGrafted dermal fibroblasts (labelled green) shown supporting new hair follicle formation. Fibroblasts are unremarkable looking cells found in most tissues in the body, where they are mainly concerned with making the collagen that supports other cell types. The cells all look alike yet are functionally diverse, prompting the question, is there just one cell type responding differently to different stimuli, or do individual cells specialize? A transplantation and lineage tracing study in mice now shows that skin connective tissue arises from two distinct fibroblast lineages that also contribute differentially to skin development and repair after injury. One cell type forms the lower dermis and the other the upper dermis. The latter lineage is required for hair follicle production and is shown on the cover in green surrounding new hair follicles and contributing to the smooth muscles (red) that contract to make hair follicles stand on end. In wounded adult skin, the initial wave of dermal repair is mediated by the 'lower' lineage, which may explain the absence of hair follicles in newly closed wounds. The authors develop a comprehensive lineage tree for all fibroblast-derived cell types in mouse dermis, including smooth muscle cells and adipocytes. COVER: Ryan Driskell, King’s College London5 I  ~3 p  B& F

' X4 E- W3 `8 G/ \' Q( a4 R! O/ R; f1 E7 W1 l& A' X

游客，如果你要查看本帖隐藏内容请回复

懵懂干细胞

感谢分享

pujvzi

thanks
. X) H, C, M5 Q

sysuhoo

极好资料

stwgch1987

看看

xiangchou812

感谢分享，学习一下！！

袭常

楼主好人~~

FionaZheng

终于要开始我的研究生涯啦啦啦

ljs

下载了

Boas

感谢楼主分享。