英国开展利用干细胞治疗心脏病研究

细胞海洋

作者：yangtao 来源：生物谷 2014-2-24 7:03:20 2 ]/ Y. I. y" M. C; z
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2014年2月24日讯 /生物谷BIOON/ --英国伦敦科学家最近启动了有史以来最大规模的干细胞治疗心脏病的研究。此次将有来自欧洲11国的超过3000名患者将参与这一计划。研究人员解释说，医生将从患者骨髓中抽取患者自身的干细胞并注射到患者心脏部位，以修复心脏病患者受损组织。而根据有关部门统计，心脏病已经成为影响英国人健康的头号杀手。而该项计划的负责人介绍说，自从干细胞技术问世以来，一直没有一项大型的临床计划来证明该技术对心脏病治疗的帮助，而此次计划则能够弥补这一空白。研究人员估计，干细胞治疗手段将使心脏病致死率降低25%，同时还能有效改善由心脏病而引起的血管变脆弱和心肌受损等并发症。另一方面，医学专家还表示这一技术的成熟有利于降低心脏病医疗成本。
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这一研究计划结果将于未来五年内公布。（生物谷Bioon.com）! l* t' `5 H) A7 d2 \
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详细英文报道：$ n- }% _- s' F8 j" b$ Q# a

: J5 I* b7 s  x3 X- E0 ZThe biggest ever stem cell trial involving heart attack patients has got under way in London. The study, which will involve 3,000 patients in 11 European countries, should show whether the treatment can cut death rates and repair damaged tissue after a heart attack.
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5 C7 T0 U4 [) y3 k& R4 ?3 nAll the patients will have standard treatment to widen their narrowed arteries, which involves inserting a small tube called a stent. In addition, half the patients will have stem cells taken from their bone marrow and injected into their heart.
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This will happen within days of them suffering a heart attack.( B! ]" I4 s2 _( o1 O' z$ P

7 G. N. `. f; @' k7 E. V/ lIt's fantastic to be part of this trial": b; T( k3 J2 \
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"It's fantastic to be part of this," said Neal Grainger, 54, from Essex, who was the first patient in the UK to be treated.; C, U# X2 a% Y; u3 ~! j5 U+ C  @
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UK's biggest killer+ H0 e$ R' F1 H) s) `
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He had an infusion of his bone marrow stem cells at the London Chest Hospital just days after his heart attack last month.
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"It's strange having something taken out of you and then put back, but I hope it helps me and a lot of others."
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6 L1 C+ c5 p+ G" }Cardiovascular disease is the biggest killer in the UK.
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During a heart attack, a fatty plaque causes a blood clot inside an artery, starving heart muscle of oxygen and leaving scar tissue.8 C8 N4 s, \! m% G: a# A/ M

! U+ Y- z' o/ a) FAlthough more and more patients are surviving heart attacks, they can be left considerably weaker because heart muscle has been permanently damaged.
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Fluid build-up on the lungs is another problem and patients are often on medication for life.
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$ J. }& k) C0 q. {There have been dozens of smaller trials using stem cells to treat heart attack patients.
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5 j# J2 X5 z. N6 F$ \'Definitive trial'
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An analysis by the Cochrane Collaboration in 2012 suggested the treatment offered "modest improvement".
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But many trials involved just small numbers of patients.
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8 |' v  p2 Q* c"This is the definitive trial," said Prof Anthony Mathur, director of cardiology at Barts Health NHS Trust and chief investigator for the trial.  A4 A8 s4 u# [, F
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"After 15 years of research we will now have a clear answer. We hope to show that stem-cell injections can cut the number of people dying from heart attacks by 25%.# V. v0 j) {* O2 K9 P$ h0 ~
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"If it works, it would open up a whole new branch of medicine, and give heart attack patients an entirely new treatment."1 e* h5 U4 J  l* H4 }# }; I# s
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It is unclear exactly how a patient's own bone marrow stem cells might help repair their heart.
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7 K$ _% [* N5 O3 }+ wDonor adult stem cells have been used successfully for decades in bone marrow transplants, but in that situation it is a like-for-like replacement.
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* d+ L1 _) h. B! {Expecting these cells to survive in the heart and transform into specialised heart cells is a huge challenge.
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/ i6 v( k9 o" R" N3 ]- v! t'Could save NHS money'
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" S1 {6 z* Z5 `& Y* M/ c  m* N9 jOne theory is that they release chemical signals that enhance the activity of the heart's own stem cells.( e" Q/ K! J5 s* Q& d

" j' K" D# S. N7 n* H# ?" A0 KUniversity College Hospital in central London and King's College Hospital in south London are the two other centres in Britain taking part.
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& J) j( @* x7 a% eThe trial includes hospitals in other major European cities such as Paris, Frankfurt, Barcelona, Milan and Copenhagen.
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* w3 o( L( y9 y2 |& a' V0 eJohn Martin, professor of cardiovascular medicine at University College London and adjunct professor of medicine at Yale, said: "This trial does not have the backing of the pharmaceutical industry as there is no money in it for them. You can't patent a patient's own cells.
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"So not only could this treatment save lives it could also save the NHS money."6 q  v' P: B9 [

" }1 ~6 q& h. K% n+ d6 C8 ZThe study, known as the BAMI (bone acute myocardial infarction), has received nearly ?5m from the European Commission.
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The results will be announced in five years.
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hao880611

回复 细胞海洋 的帖子
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* ~$ Y4 J$ J+ z, R0 N研究人员解释说，医生将从患者骨髓中抽取患者自身的干细胞并注射到患者心脏部位，以修复心脏病患者受损组织。这个过程。。。。

uslzhang

自体骨髓干细胞治疗心肌损伤，韩国前几年就已有产品上市了