|
- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
|
本帖最后由 细胞海洋 于 2014-5-5 08:45 编辑 ! z' H% h, D; U2 B- v3 H
& w8 R( e6 [5 T' m7 {2 x2014年5月1日 Nature
0 }# S r. x5 B" ^
) T% ~7 G( K; m- m4 r
7 C1 Q% J* k) I7 e The striking motions represented in Heel Daoyin, a kinetic sculpture by Peter Jansen, are reminiscent of limb oscillations seen in the absence of presynaptic inhibition. Humans and other animals execute limb movements with a seemingly effortless precision that relies on sensory feedback and its refinement by inhibitory microcircuits. A new study identifies presynaptic inhibition in the spinal cord, a regulatory filter mediated by Gad2-expressing GABAergic interneurons that form connections with the terminals of sensory afferents, as part of a hardwired gain control system crucial for the smooth execution of movement. Thomas Jessell and colleagues demonstrate that activation of Gad2-expressing neurons inhibits neurotransmitter release from sensory afferents. Selective ablation of these neurons in mice causes pronounced oscillations during goal-directed forelimb reaching movements, a behaviour captured by a model of sensory feedback at high gain. Cover: Peter Jansen, www.humanmotions.com5 Y% F; Y5 B1 ], U: W: L, ]
) y4 g W' _! _ \! s6 k/ T1 x! G" \0 }) \
|
-
总评分: 威望 + 20
包包 + 20
查看全部评分
|
发表于 2014-5-4 20:52
发表于 2014-5-4 21:49
