2014年5月1日 Nature

nero1981

! U9 U* a8 b* J

3 l- l6 L0 o9 T$ @- ?2014年5月1日 Nature
* T8 H" T7 k2 f, K; @" x6 s0 l0 w( |- ^+ \, P' R$ x; V; a$ r
5 E" ~& B+ d+ S, \
The striking motions represented in Heel Daoyin, a kinetic sculpture by Peter Jansen, are reminiscent of limb oscillations seen in the absence of presynaptic inhibition. Humans and other animals execute limb movements with a seemingly effortless precision that relies on sensory feedback and its refinement by inhibitory microcircuits. A new study identifies presynaptic inhibition in the spinal cord, a regulatory filter mediated by Gad2-expressing GABAergic interneurons that form connections with the terminals of sensory afferents, as part of a hardwired gain control system crucial for the smooth execution of movement. Thomas Jessell and colleagues demonstrate that activation of Gad2-expressing neurons inhibits neurotransmitter release from sensory afferents. Selective ablation of these neurons in mice causes pronounced oscillations during goal-directed forelimb reaching movements, a behaviour captured by a model of sensory feedback at high gain. Cover: Peter Jansen, www.humanmotions.com6 {: U" H* j- {5 e

6 R0 d, z: z3 d8 o" o' p0 M

游客，如果你要查看本帖隐藏内容请回复

; t0 e* C( i6 l/ a7 u

懵懂干细胞

谢谢分享

exin11

xiangchou812

感谢分享！！

zorro

thank

sysuhoo

谢谢分享

287762010

感谢分享~~~~~~~··

zhzliang

谢谢分享

youngyoungzhao

非常感谢, A) k$ X" U3 I- U* {6 Y5 X

yuheng

谢谢