2014年5月1日 Nature

nero1981

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3 y) o! e# J7 s4 m2014年5月1日 Nature
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/ ~; U) Y. d) T) H The striking motions represented in Heel Daoyin, a kinetic sculpture by Peter Jansen, are reminiscent of limb oscillations seen in the absence of presynaptic inhibition. Humans and other animals execute limb movements with a seemingly effortless precision that relies on sensory feedback and its refinement by inhibitory microcircuits. A new study identifies presynaptic inhibition in the spinal cord, a regulatory filter mediated by Gad2-expressing GABAergic interneurons that form connections with the terminals of sensory afferents, as part of a hardwired gain control system crucial for the smooth execution of movement. Thomas Jessell and colleagues demonstrate that activation of Gad2-expressing neurons inhibits neurotransmitter release from sensory afferents. Selective ablation of these neurons in mice causes pronounced oscillations during goal-directed forelimb reaching movements, a behaviour captured by a model of sensory feedback at high gain. Cover: Peter Jansen, www.humanmotions.com3 g" x: `/ |9 w- a& Q8 I+ b4 R( N
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