干细胞之家 - 中国干细胞行业门户第一站

 

 

搜索
朗日生物

免疫细胞治疗专区

欢迎关注干细胞微信公众号

  
查看: 594786|回复: 260
go

Two vesicle pools for neurons [复制链接]

Rank: 7Rank: 7Rank: 7

积分
威望
0  
包包
3465  
楼主
发表于 2009-3-6 09:02 |只看该作者 |正序浏览 |打印
KAVALALI/ELSEVIER. g$ u  `9 y( }2 l/ C

) X4 B* U1 L: M$ j" E3 r' H! KYildirim Sara, Ege Kavalali, and colleagues (University of Texas Southwestern Medical Center, Dallas, TX) show that nerve terminals possess two independent vesicle populations: one for activity-dependent neurotransmitter release, and one for spontaneous release.$ `* b" j6 z4 |$ q9 A- n

( A" |1 a3 K: P5 k" i* i* uActivity-dependent release is the typical action potential–generating mechanism. But occasionally a vesicle leaks its contents without provocation. Most scientists figured these events〞which affect synaptic development and inhibit translation in dendrites〞reflect the occasional escape of a vesicle primed for activity-dependent release. But the new results reveal that spontaneously released vesicles comprise a pool of their own.
3 W: G) q' I) K% v% S1 v9 e5 }# l/ r3 ?+ j% ^& [
The two pools were distinguished by their filling mechanism: vesicles loaded with dyes by spontaneous endocytosis were then unloaded more rapidly by spontaneous release than by stimulated release. Activity-dependent endocytosis filled vesicles that were more rapidly unloaded by stimulated release. Blocking neurotransmitter refilling into vesicles at rest only affected spontaneous release, suggesting that the pools do not intermix.! y9 i3 A- j# p+ V7 R

: A9 z9 |6 Q. b' `Spontaneous vesicles may be defective in fusion yet occasionally fuse where and when they should not. The two pools looked the same by EM and were similarly localized, so the differences probably lie in lipid or protein content. How the differences originate is unclear. "There could be two recycling pathways" such as local and endosomal routes, says Kavalali. "Or  might just be the use-dependent accumulation of defective vesicles over time."6 K" m$ X# L! s( a3 }
; d, j" Z! f- r& u- d
Reference:8 S- A/ Z+ \2 \2 B
4 W4 c" Y2 {0 s/ P
Sara, Y., et al. 2005. Neuron. 45:563–573.(Vesicles formed by spontaneous (left) or)

Rank: 2

积分
123 
威望
123  
包包
1650  
261
发表于 2025-5-30 10:29 |只看该作者
支持一下吧  

Rank: 2

积分
87 
威望
87  
包包
1725  
260
发表于 2025-5-26 06:50 |只看该作者
不错 不错  比我强多了  

Rank: 1

积分
威望
0  
包包
1511  
259
发表于 2025-4-21 09:13 |只看该作者
干细胞之家微信公众号
我顶啊。接着顶  

Rank: 2

积分
127 
威望
127  
包包
1719  
258
发表于 2025-3-13 02:21 |只看该作者
是楼主原创吗  

Rank: 2

积分
123 
威望
123  
包包
1661  
257
发表于 2025-2-27 21:08 |只看该作者
21世纪,什么最重要——我!  

Rank: 2

积分
117 
威望
117  
包包
1669  
256
发表于 2025-2-18 00:58 |只看该作者
好人一个  

Rank: 2

积分
73 
威望
73  
包包
1561  
255
发表于 2025-2-14 08:40 |只看该作者
看贴回复是好习惯  

Rank: 2

积分
75 
威望
75  
包包
2118  
254
发表于 2025-1-28 06:08 |只看该作者
今天临床的资料更新很多呀

Rank: 2

积分
61 
威望
61  
包包
1581  
253
发表于 2025-1-23 13:08 |只看该作者
今天没事来逛逛  
‹ 上一主题|下一主题
你需要登录后才可以回帖 登录 | 注册
验证问答 换一个

Archiver|干细胞之家 ( 吉ICP备2021004615号-3 )

GMT+8, 2025-6-10 20:31

Powered by Discuz! X1.5

© 2001-2010 Comsenz Inc.