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本帖最后由 细胞海洋 于 2014-7-1 09:55 编辑 / J, j+ P" v& R" D8 V$ V. h. e
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2014年6月26日 Nature
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Aspergillus versicolor fungus conidiophore and spores, stained with pactophenol cotton blue. Infection with Gram-negative pathogens bearing metallo-β-lactamases such as NDM-1 and VIM is a growing public health problem and threatens the use of penicillin, cephalosporin and carbapenem antibiotics to treat infections. Here, Gerard Wright and colleagues report a screen for naturally produced inhibitors of NDM-1 in an extensive collection of DMSO-dissolved natural product extracts derived from environmental microorganisms. One extract (from A. versicolor) exhibited a particularly potent anti-NDM-1 activity and was identified as aspergillomarasmine A (AMA), a natural product first reported some 50 years ago associated with leaf wilting. AMA is a rapid and potent inhibitor of both NDM-1 and VIM-2, and the authors find that AMA fully restores antibiotic efficacy in vitro and in vivo against bacterial pathogens possessing either VIM- or NDM-type resistance genes. AMA is non-toxic and well tolerated, making it a realistic prospect as an antibiotic adjuvant. Cover: Dennis Kunkel Microscopy, Inc./Visuals Unlimited/Corbis.
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发表于 2014-6-30 21:37
