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本帖最后由 细胞海洋 于 2014-7-1 09:55 编辑 & f/ |2 D0 C4 v e% ]2 ]7 J5 ^
; ?' ~" {" o' I& g. C" B( l2014年6月26日 Nature
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; z% C o4 Y& N) lAspergillus versicolor fungus conidiophore and spores, stained with pactophenol cotton blue. Infection with Gram-negative pathogens bearing metallo-β-lactamases such as NDM-1 and VIM is a growing public health problem and threatens the use of penicillin, cephalosporin and carbapenem antibiotics to treat infections. Here, Gerard Wright and colleagues report a screen for naturally produced inhibitors of NDM-1 in an extensive collection of DMSO-dissolved natural product extracts derived from environmental microorganisms. One extract (from A. versicolor) exhibited a particularly potent anti-NDM-1 activity and was identified as aspergillomarasmine A (AMA), a natural product first reported some 50 years ago associated with leaf wilting. AMA is a rapid and potent inhibitor of both NDM-1 and VIM-2, and the authors find that AMA fully restores antibiotic efficacy in vitro and in vivo against bacterial pathogens possessing either VIM- or NDM-type resistance genes. AMA is non-toxic and well tolerated, making it a realistic prospect as an antibiotic adjuvant. Cover: Dennis Kunkel Microscopy, Inc./Visuals Unlimited/Corbis.8 \ W0 }) @, I0 V+ t: G) R% h
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发表于 2014-6-30 21:37
