
- 积分
- 13
- 威望
- 13
- 包包
- 49
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Targeted therapies that deliver the expected anti-tumor
1 m# U6 y7 e+ Y* x) W5 Eeffects while mitigating the adverse effects are taking2 \8 _" a6 U& m0 D
the cancer world by storm. The need for such therapies
; z2 |* {8 n3 s% din non-small cell lung cancer (NSCLC), where systemic
4 {# @" @. ? P1 V8 gcytotoxic chemotherapies still remain the backbone of3 ?8 \; i3 p2 C# u/ N' C/ K
management, is felt more than ever before. Runway
; B. i/ u. m5 }; a Isuccess of immunotherapies such as Ipilimumab for' f3 Z2 b' \$ P5 P- j) v6 {
melanoma has brought excitement among oncologists.
; m6 A- L0 t: D) `( nImmune-based treatments are in various stages of5 m) v' D6 [5 W
evaluation for NSCLC as well. Immunotherapies using
3 m' A* e+ @/ f) j+ ^strategies of antigen based or cell based vaccines, and
7 c+ w. a* x: N* ~, ? Sblocking immune checkpoints are of substantial interest.
, [# h2 P8 D# Q4 g: X# E$ P3 ]4 X0 }Meaningful clinical responses are yet to be reaped
7 {0 R7 t8 f. }$ T- a9 ?1 h/ e% afrom these new treatment modalities.
3 \. d1 n8 q" I" c+ w) @% ~3 C z, q. R& C9 g
U3 z0 U5 F" U9 t* x+ Z @Lung cancer is the leading cause of cancerdeath
4 i5 W3 B) v( `& N7 S* @' T% sworldwide. Majority of these patients have nonsmall
H B/ h1 q9 N- a2 p. s) g9 Qcell lung cancer (NSCLC). Traditional chemotherapy& a" V! \2 N% v8 u$ s
is limited by its high toxicity. Emerging data have; o/ {; `# v( C. o& E! s
demonstrated promising outcome of immunotherapy in
3 k0 y& Q s- m8 RNSCLC. This review delineated the rationale and potential$ Y) o4 N* P! H
targets of cancer immunotherapy, with a summary
% P, h6 k0 J c d2 R# Uof immunotherapeutic agents for treatment of NSCLC.$ E5 A+ `8 k0 N# U
Protein/peptide-based and cell-based vaccines, as well# i# I; S' c: S5 R* b" o% p% {$ _
as immune checkpoint targeted agents such as Ipilimumab8 ?" S3 n& s. ~
and PD-1 pathway inhibitors were discussed. In
7 C# R, V7 ~) y3 t" @addition, we reviewed ongoing immunotherapy-based; j0 J7 H5 D+ m7 {* O
studies including several major phase Ⅱ/Ⅲ clinical trials,0 l8 ^0 K! J7 A3 x/ o# D7 o
results of which will be available soon for incorporation* g8 }' Z8 y7 c
into clinical practice. |
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