Occurrence of cancer at multiple sites: towards distinguishing multigenesis from

刘实

Zhang WK, Zhang C, Zhang JJ, Liu SV.
7 }- J5 v: _4 `! n; w" eDepartment of General Surgery, Union Hospital, Huazhong Science and Technology University, Wuhan, China. zhangweikang100@yahoo.com.cn- s9 U8 c& o" \& O
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BACKGROUND: Occurrence of tumors at multiple sites is a hallmark of malignant cancers and contributes to the high mortality of cancers. The formation of multi-site cancers (MSCs) has conventionally been regarded as a result of hematogenous metastasis. However, some MSCs may appear as unusual in the sense of vascular dissemination pattern and therefore be explained by alternative metastasis models or even by non-metastatic independent formation mechanisms. RESULTS: Through literature review and incorporation of recent advance in understanding aging and development, we identified two alternative mechanisms for the independent formation of MSCs: 1) formation of separate tumors from cancer-initiating cells (CICs) mutated at an early stage of development and then diverging as to their physical locations upon further development, 2) formation of separate tumors from different CICs that contain mutations in some convergent ways. Either of these processes does not require long-distance migration and/or vascular dissemination of cancer cells from a primary site to a secondary site. Thus, we classify the formation of these MSCs from indigenous CICs (iCICs) into a new mechanistic category of tumor formation - multigenesis. CONCLUSION: A multigenesis view on multi-site cancer (MSCs) may offer explanations for some "unusual metastasis" and has important implications for designing expanded strategies for the diagnosis and treatment of cancers.. v" }5 q- z* R4 l) i( h; x

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passenger101

I have following questions：
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Question 1 on "Some MSCs may appear as unusual in the sense of vascular dissemination pattern. "+ o# ~( l: v. V
I don't know this type of unusual MSCs.  Could you please give some introduction about this type of cancers?  Please give examples and explain how different from the vascular dissemination pattern? what the percentage it may account in patients? How it may affect patients' health?
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Quesiton 2: In the above abstract, you gave some logical possibility of MSC origins, but didn't provide any evidence. The study is marked by "may".  The abstract appears to be a result of a brain storm(侃大山）, but not a finding? It's 2 weeks after your post. Could you please post the full content? I'm interested in learning more about it.

koppera

谢谢

shujing

值得期待