干细胞之家 - 中国干细胞行业门户第一站

 

 

搜索
干细胞之家 - 中国干细胞行业门户第一站 干细胞之家论坛 免疫细胞治疗专区 Cell:癌症免疫疗法和靶向疗法联合治疗癌症(附原文)
朗日生物

免疫细胞治疗专区

欢迎关注干细胞微信公众号

  
查看: 20734|回复: 2
go

Cell:癌症免疫疗法和靶向疗法联合治疗癌症(附原文) [复制链接]

Rank: 2

积分
173 
威望
173  
包包
476  
楼主
发表于 2015-4-15 08:39 |只看该作者 |倒序浏览 |打印
本帖最后由 细胞海洋 于 2015-4-15 14:35 编辑
' o' c2 u/ i, O8 B0 E" c  s6 z- Q; U! d/ V
近日,刊登在国际杂志Cell上的一篇研究论文中,来自德克萨斯大学MD安德森癌症中心的研究人员通过研究表示,利用免于免疫系统攻击癌症的药物同基因组靶向疗法相结合或许可以更好地帮助治疗癌症患者。: j2 I" M7 W/ p" @$ |9 c4 |1 R; O
% \& g& Q+ S0 B/ |3 d: }# X+ W3 w
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential! t* F! Q( ?' ]+ D2 b

) {# Z  J& N' TPadmanee Sharma, James P. Allison/ ]) X$ W' e7 n; [6 R; n# K& f; Q

: d( x& w$ ~* D6 Q# ?2 w, \9 DResearch in two fronts has enabled the development of therapies that provide significant benefit to cancer patients. One area stems from a detailed knowledge of mutations that activate or inactivate signaling pathways that drive cancer development. This work triggered the development of targeted therapies that lead to clinical responses in the majority of patients bearing the targeted mutation, although responses are often of limited duration. In the second front are the advances in molecular immunology that unveiled the complexity of the mechanisms regulating cellular immune responses. These developments led to the successful targeting of immune checkpoints to unleash anti-tumor T cell responses, resulting in durable long-lasting responses but only in a fraction of patients. In this Review, we discuss the evolution of research in these two areas and propose that intercrossing them and increasing funding to guide research of combination of agents represent a path forward for the development of curative therapies for the majority of cancer patients.
  [3 i  d$ A( ~$ E0 ~2 q
9 U* S# M7 B! k) q: q& H
# h1 i$ Y" C8 w0 X6 F/ T全文下载:
- }1 G" w2 q1 Z0 ]
附件: 你需要登录才可以下载或查看附件。没有帐号?注册
已有 1 人评分威望 包包 收起 理由
细胞海洋 + 5 + 15 极好资料

总评分: 威望 + 5  包包 + 15   查看全部评分

Rank: 2

积分
139 
威望
139  
包包
450  
沙发
发表于 2015-4-15 08:57 |只看该作者

Rank: 1

积分
26 
威望
26  
包包
149  
藤椅
发表于 2015-4-21 11:43 |只看该作者
谢谢
‹ 上一主题|下一主题
你需要登录后才可以回帖 登录 | 注册
验证问答 换一个

Archiver|干细胞之家 ( 吉ICP备2021004615号-3 )

GMT+8, 2025-6-9 21:14

Powered by Discuz! X1.5

© 2001-2010 Comsenz Inc.