'Cell explosions' can trigger instant cancers * O8 p6 |$ Y) y7 `$ H7 c3 }9 tJanuary 8th, 2011 . v/ X9 R/ n; O r
IANS http://www.deccanchronicle.com/g ... instant-cancers-193 9 k1 |9 t( L7 i- s( ]: e+ z( vBritish scientists have decoded the mystery of why 'instant cancers' seemingly appear out of nowhere.3 W2 [( O2 l/ f0 _7 }$ H9 A) I! E0 g
The finding from the Wellcome Trust Sanger Institute in the UK contradicts the long-held theory that thousands of mutations over a lifetime cause cancer. * k" T3 K8 N s0 |
It also helps explain why some people are diagnosed with cancer only months after x-rays or other tests fail to detect traces of the disease, the journal Cell reports. ; M3 V4 K' L: ~, a4 O0 YThe discovery was based on the genetic flaws in 750 tumours. In most cases, the damage to chromosomes upheld the conventional picture of cancer creeping up over the years, according to the Daily Mail. 7 M8 P, Z& ]0 I% g8 p2 ~But at least one tumour in 40 didn't fit the pattern. Instead, the damage appeared to have been done almost overnight. # C& E- B( O$ ]. u1 P( z# AResearcher Peter Campbell said: "The results astounded us. It seems that in a single cell, in a single event, one or more of the chromosomes explode - literally into hundreds of fragments." ) u5 r. F8 e2 c$ eIf the cell then botches the repair, stitching the fragments back together in a 'higgledy piggledy' fashion, the damage to its genome, or cache of DNA, leaves it ripe for the rapid development of cancer.$ X( o( F4 R) D
Campbell said: "They attempt to reconstruct the unreconstructable and they wind up with a disastrous genome that shortens the road to cancer." : S3 O) ?- f# J" T8 N8 nThe phenomenon is particularly common in bone cancers, where the distinct pattern of damage is seen in up to one in four cases. But it is thought to be to blame for more than one in 40 of all cases of the disease. 0 x% d6 u6 o p4 u8 ]: j4 D% ` $ q- T# l: g C# C( k- Z ( s6 @2 L/ `, q: b2 gThe Mystery of "Instant Cancers" 6 ?$ v: p6 j; w( Z$ q0 u4 x#0, by emeline, 07 January 2011 09:52 AM http://tinfoilpalace.eamped.com/ ... of-instant-cancers/+ F' E2 |' L1 q- x( y$ a0 L: D% c
Why some cancers seems to develop in an instant - cells can explode wreaking havoc in DNA : f% U; ^$ X1 _0 x9 z7 p0 B4 H: uThe mystery of 'instant cancers' - tumours that seem to appear out of nowhere - has been solved by British scientists.; g) ~4 y/ t% n* M
In some cases, a single apocalyptic ‘explosion’ in a cell can cause as much damage to the DNA as decades of hard living. . j$ T0 _1 X0 k, I) |; e[attach]20130[/attach]' L; s% d y% X* N2 H; x
A model of a DNA Molecule. Scientists have found one in 40 cancers could develop rapidly after an unexpected cell explosion causes DNA damage, \* f# I- W! @
The finding, from the Wellcome Trust Sanger Institute near Cambridge, contradicts the long-held theory that cancer is the consequence of hundreds, or thousands, of mutations that build up over a person’s lifetime. 9 ], Y8 _" i$ N7 h. y2 o7 xIt suggests that no matter how healthy some people try to be, fates is conspiring against them. And it helps explain why some people are diagnosed with cancer only months after x-rays or other tests found no trace of the disease. 0 u8 N, c9 {2 p7 R4 fThe discovery was made from the study of the genetic flaws in 750 tumours.( g- m2 K& Z/ r' S \) p
In most cases, the damage seen to the chromosomes fitted with the conventional picture of cancer creeping up over many years.; C% {4 a# J9 u, j& f
But at least one tumour in 40 didn’t fit the standard pattern, the journal Cell reports. 2 a4 p: ?# R7 ?! A( ~( T1 E$ X" S3 B5 i
Scientists ‘Crack’ Mystery behind Instant Cancers 8 D) Z8 T7 M$ j( ]- u
Submitted by Davell Wilkins on Fri, 01/07/2011 - 08:57 http://topnews.us/content/232009 ... ind-instant-cancers ! p) J- l5 m) N4 R* w[attach]20131[/attach]- s1 d% }; E9 U6 ^: z7 a# p) E
Claiming to have cracked the suspense shrouding the occurrence of tumours that appear from nowhere, British scientists say the so-called 'instant cancers' may be due to an abrupt ‘cell explosion’ called DNA damage. This sudden cell explosion could be a cause of cancer in one in 40 cases. $ h% q& ^; f* m/ Y9 v! t, oDone by the Wellcome Trust Sanger Institute near Cambridge, the discovery took into account the study of the genetic flaws in as many as 750 tumours.$ T+ F* q& e$ J, E0 j L' s
Also, this discovery contradicts the prevailing theory that the lethal disease cancer resulted out of hundreds, or even thousands, of cell alternations that take place in a human body. ! g9 f+ D# N% X: M SAccording to the scientists, one in 40 cancer cases could be a result of unexpected cell explosion, which subsequently rapidly damages the DNA. And in a few cases, the scientists say, the damage caused to the DNA by a single apocalyptic ‘explosion’ in a cell was equivalent to about as much as 10 years of hard living.0 u0 v5 K) a; g0 D2 i
“It seems that in a single cell in a single event, one or more chromosomes basically explode - literally into hundreds of fragments”, said study leader Dr. Peter Campbell, from the Wellcome Trust Sanger Institute in Hinxton. , Z7 e! N5 J1 x1 A' EAnd in some cases, DNA repair machinery tries to attach the chromosomes back together but gets it disastrously wrong, says Dr. Campbell, adding out of the hundreds of mutations that result, several promote the development of cancer. , g+ J+ h4 {, Y
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+ ^5 ~* q" ~' z4 B6 W: |. J# T) ]( p 作者: stemcellfamily 时间: 2011-1-9 03:29
应该是这篇,评论把文章里面的称呼都换了……哈哈。) H X- d8 e0 U0 `8 e* Z# r m
( t! t% }8 _6 p, O+ k6 c[attach]20139[/attach] ( A) Z: r# a& A/ w. @/ k) OCELL 144(1) pp. 27 - 40 ( @/ H1 }' S% L: p4 ~Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development作者: tpwang 时间: 2011-1-9 10:03
回复 小鲁鲁 的帖子 % V* M# Y6 b, \0 m) a1 S2 f* T. I. G' _4 L2 B2 G
感谢介绍与原文。翻译介绍的比较简单与“媒体化”,呵呵。 ( _; w0 h4 `9 S; X" G3 }7 [9 M( o# D3 x$ b7 W0 l
We would predict that inthe case of chromothripsis, the overwhelming / [% S5 ?9 N, H+ O; t8 b7 j, r7 Fmajority of cells suffering such spectacular genomic damage would 8 W. R( t6 ~0 ^4 _- L2 J. q3 S
either die or acquire more detrimental than advantageous variants.; w/ P: D% E7 M3 R
However, very rarely, a cell might acquire one or more cancercausing , b1 M7 y7 M7 _- Z- L5 X6 blesions from such an event and this clone would then have taken a 0 T$ y* ]+ p" f' {" F3 p: ?considerable leap along the road to cancer. There would still be the 9 S/ i! p& q! ?1 h* W2 C
need for additional mutations in cancer genes, exemplified by the # J f& C+ e, K4 `2 G4 H+ N
second hits in CDKN2A seen in the chordoma and thyroid cancer . C& u. j6 j$ T. t
samples (Figure 7), but we might anticipate the emergent tumor 1 U& k- L+ G. c; O/ I( v" h$ `/ N
having shorter latency. 0 }2 g! T/ u. R$ v+ z 2 k) |* M, M, e& d看起来是说特定过程的一个灾难性事件导致rearrangements,修复 ) c. v+ u7 d8 }' c1 C; V过程太急太乱,然后再遇到进一步的突变,应该说是一个灾难性! v4 |' O! }) g6 x' K
事件引发的加速癌变过程。" t7 e+ ~# C) N
8 n I4 w8 Z( iThe genomic regions involved in each example are sharply circumscribed, / H5 Q }. |# e# L0 C% X& Z% D& G/ }whether it be a whole chromosome, a chromosome arm or a region of just ) |$ r% ~7 |% [% S& t% O+ V% i7 Z0 x
a few megabases within a chromosomal band. It seems likely that the insult # ]' W/ g, Q E* m) i( M; Y: v
occurs while the chromosomes are condensed for mitosis. 4 S( V- U8 Y7 ?( x, ]& | : ^$ o- _. C1 Y3 ~# j; G这个可能情景是否有延伸的意义。。。作者: jiandong2001 时间: 2011-1-9 11:15
太强了,这么快找到原文了作者: sunsong7 时间: 2011-1-9 18:11
本帖最后由 sunsong7 于 2011-1-9 18:12 编辑 ( m$ o& ^$ j. ] r. p8 { c% c) \! Y/ x5 [
呵呵,大家找到家的感觉啦!% `: Q( A3 U: B
如果说“细胞爆炸”造就了"急性癌症",那么“基因爆炸”或许造就了新的生命...作者: shulp2211 时间: 2011-1-9 20:50