, v K% E l8 E( T V8 G! pKipnis 指出“对这些脉管进行活体成像对于证实它们的功能至关重要,没有与神经科学助理教授、BIG中心成员Tajie Harris的合作不可能做到这一点。” $ `, f8 e Z J3 D - ~1 p( z% R2 ?7 v0 N; @ h3 s阿尔茨海默氏症,自闭症,多发性硬化症以及其他 - d# g; W; L" m \/ K; [# B8 A2 T% F. X ) H, ?: k% B% g4 X意外发现淋巴管的存在提出了许多现在需要解答的,关于大脑和疾病运作机制的问题。以阿尔茨海默氏症为例。Kipnis 说:“在阿尔茨海默氏症中,大脑内累积了一些大的蛋白质团块。我们认为有可能是因为这些脉管无法有效清除它们,它们才在大脑中累积。”他指出这些脉管看起来随年龄而改变,因此它们在衰老中所起的作用是另一个有待探索的途经。鉴于出现了科学界一直坚持不存在的东西,必须要重思从自闭症到多发性硬化症等众多其他的神经系统疾病。 4 _9 V* l6 m% \7 f8 J 6 C: l/ K9 I9 n1 | ~2 m9 W. Z U参考文献我要补充文献7 y! a, r! q2 Y) w) n1 H& c( O. \
Structural and functional features of central nervous system lymphatic vessels ' K9 }( v6 {7 |( h" m* E# l" Q) zStructural and functional features of central nervous system lymphatic vessels" l9 H: e, u7 ~; {
文献检索:doi:10.1038/nature14432% f9 k9 s i G4 }
One of the characteristics of the central nervous system is the lack of a classical lymphatic drainage system. Although it is now accepted that the central nervous system undergoes constant immune surveillance that takes place within the meningeal compartment1, 2, 3, the mechanisms governing the entrance and exit of immune cells from the central nervous system remain poorly understood4, 5, 6. In searching for T-cell gateways into and out of the meninges, we discovered functional lymphatic vessels lining the dural sinuses. These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both fluid and immune cells from the cerebrospinal fluid, and are connected to the deep cervical lymph nodes. The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the central nervous system. The discovery of the central nervous system lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction. 2 h- E) f3 H5 _' V2 C生物通/何嫱作者: luckyliu 时间: 2015-6-4 14:51