2013-4-2 Structure

nero1981

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2 April, 2013 Volume 21, Issue 48 N7 U0 ]6 X# b( o
On the cover: The nuclear pore complex (NPC; silver mesh) governs the trafficking of macromolecules between the nucleus and cytoplasm in eukaryotes and plays vital roles in myriad physiological processes. A hybrid approach including X-ray crystallography, small-angle X-ray scattering, molecular dynamics simulation, and electron microscopy revealed the structure and conformational dynamics of yeast Nup192 (orange), a major component of the NPC inner ring. Functional experiments suggest a role for Nup192 in modulating the permeability of the NPC's central channel. The cover image was created by Graham Johnson, QB3 Faculty Fellow at the University of California, San Francisco (UCSF). See Sampathkumar et al., pp. 560–571.
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