临床治疗的间充质干细胞

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主题：临床治疗的间充质干细胞* ?. b9 O1 I. |4 Q6 m$ Y8 J

2 Z) K" J6 L. J/ A说明：原文来源自BIOMEDICAL ENGINEERING，由干细胞之家新闻小组成员deron翻译（转帖请注明）。
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翻译内容：间充质干细胞（MSCs）属多功能干细胞，目前正在临床探索作为一种新方法治疗多种免疫调节疾病。MSCs起初是作为一种再生治疗手段用于骨骼组织修复，最近新发现其可用于调节内源性组织和免疫细胞。临床前期研究其作用机制表明：MSCs移植介导的治疗效果具有短时性的特点，并且和MSC与受体细胞之间功能性旁分泌交互作用相关。因此，作为药物导向微粒的MSCs可应用药物代谢动力学的模式来预测MSC移植的治疗活性，这也体现了其药物递送的功能。通过整合MSC的生物学、治疗和编程原则，研究致力于引领新一代的干细胞治疗手段。6 Z* t& ^! T: q# _) L: z
原摘要：Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerative therapy for skeletal tissue repair, MSCs have recently been shown to modulate endogenous tissue and immune cells. Preclinical studies of the mechanism of action suggest that the therapeutic effects afforded by MSC transplantation are short-lived and related to dynamic, paracrine interactions between MSCs and host cells. Therefore, representations of MSCs as drug-loaded particles may allow for pharmacokinetic models to predict the therapeutic activity of MSC transplants as a function of drug delivery mode. By integrating principles of MSC biology, therapy, and engineering, the field is armed to usher in the next generation of stem cell therapeutics.
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4 A& u" s" l9 L0 j6 `原文：http://www.annualreviews.org/doi ... ?journalCode=bioeng，尚无全文。0 ?8 |7 F6 C& z5 c% f

( k4 M2 _; q0 T) T) `: K) D& L说明：虽然意思都明了，但是整合出学术性的句子还是蛮有难度的，如果有翻译不到位的地方，还请大家指正。

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