PDF电子书：Genes and Common Diseases

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Genes and Common Diseases
. z4 }! X% q6 `' N0 o! jGenes and common diseases presents an up-to-date
. [4 L! c5 N. gview of the role of genetics in modern medicine,2 `  ]; B" ^  m: d
reflecting the strengths and limitations of a genetic
  s1 y  \0 i; q  b/ _: S" fperspective.
- F& {4 w$ b3 H! d8 RThe current shift in emphasis from the study of* ~: t( O/ m% W2 X5 h9 b
rare single gene disorders to common diseases
/ D5 o0 K. d+ Wbrings genetics into every aspect of modern) r* n( R/ e2 I7 J$ {" N9 u/ y
medicine, from infectious diseases to therapeutics.# V( `* ?4 i$ P: K( M  g/ E2 T
However, it is unclear whether this increasingly
0 }* l* U6 j$ _5 c+ M4 ^* P9 ?! Pgenetic focus will prove useful in the face of major+ k% _% g5 t; O5 s1 c. M
environmental influences in many common; C$ M( u% H1 F" g
diseases.
6 g9 p+ j# ]$ W2 t" [( y# VThe book takes a hard and self-critical look at. d1 c' F+ E* t
what can and cannot be achieved using a genetic
( C6 E  O( c5 a6 p0 T: {0 \4 {" A( zapproach and what is known about genetic and% e" ~* l" u2 [; @: w
environmental mechanisms in a variety of1 V  n9 O4 T7 }+ j2 y; B: q% ~1 L4 g7 y
common diseases. It seeks to clarify the goals of' |3 z* J* I1 `- Q2 q4 ^" F
human genetic research by providing state-of-the
% [" T, e$ V& yart insights into known molecular mechanisms, o4 Q6 u+ L; y1 A- S9 ]# z$ u  g( t5 C
underlying common disease processes while at the
" f4 }9 d) A+ P0 L1 ?same time providing a realistic overview of the
$ J# |, B: j: A: U/ g/ kexpected genetic and psychological complexity." l) B3 f3 B* p
Alan Wright is a Programme Leader at the MRC
4 ^  O/ U; }$ Y* p# e6 yHuman Genetics Unit in Edinburgh.
/ r8 \+ u& ]' b/ ]) j1 j5 ~Nicholas Hastie is Director of the MRC Human+ W, ^" z7 m0 X! X% E
Genetics Unit in Edinburgh.
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