研究称乳腺癌药物或可抗肺癌

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来源：新华网 发布时间：2011-1-25 16:57:34选择字号：小 中 大  
& |) j$ b( b7 J4 P2 [) [研究人员在1月24日出版的美国《癌症》（Cancer）期刊上发表文章说，常用乳腺癌治疗药物它莫西芬可能有助于降低肺癌致死风险。
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8 X  t, d- a6 z  i5 A先前研究显示，女性在绝经期采取荷尔蒙替代疗法刺激雌激素分泌，会增加患乳腺癌、肺癌或卵巢癌的风险。
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它莫西芬是一种抗雌激素，能够抑制部分乳腺癌细胞生长和分裂。研究人员假设，这类抗雌激素在阻止雌激素分泌的同时，可能降低肺癌致死风险。
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- ?2 Y! \+ p6 I0 s这个研究团队在瑞士日内瓦一家癌症统计机构选取6655名女性的数据，这些女性1980年至2003年间确诊患乳腺癌，其中3066人服用抗雌激素药物。$ q+ e3 d8 g- G5 o/ N3 z4 R

- o& d  ~" ?, ?* u) O& e研究人员追踪截至2007年12月的全部乳腺癌患者病情进展，统计其中罹患肺癌和肺癌致死人数。1 c9 S* T4 Q  f$ W3 _5 o, q

1 @2 S( D- u. J: U! X* C结果显示，与普通人群相比，这3066名服用抗雌激素药物的乳腺癌患者中，肺癌致死人数减少87%。
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研究领队伊丽莎白·拉皮蒂说，统计结果支持研究假设，即体内荷尔蒙水平与肺癌存在关联，大部分乳腺癌患者罹患肺癌，与服用孕酮等雌激素有关。. O  D2 ^& D/ Z0 C
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拉皮蒂说，如果进一步研究能够证实这些统计结果，找到抗雌激素类药物有助于缓解肺癌的证据，将对今后临床研究产生重要影响。
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: Q+ w+ W. _2 qTamoxifen May Cut Lung Cancer Deaths* H: k0 U7 B0 ?" A( [. G
Study Suggests Hormones Influence Some Lung Cancers
+ F( F% u' m9 Ehttp://www.webmd.com/lung-cancer ... aths?src=RSS_PUBLIC
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4 a! i) U& k/ R; r! e" MJan. 24, 2011 -- Tamoxifen, the medication long used to prevent the growth of breast cancer tumors, also appears to reduce the risk of dying from lung cancer, research suggests.2 H! m, L# o# b9 O) Z3 {( a
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If the link bears out in future studies, giving tamoxifen for lung cancer may become another option for doctors, the researchers say.
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2 I$ U; e- r7 d1 cThe team of Swiss and French researchers followed more than 6,000 women diagnosed with breast cancer between 1980 and 2003. The researchers found that women on tamoxifen for their breast cancer who also contracted lung cancer were 87% less likely to die from the lung cancer than women who weren't on tamoxifen.- H% A7 H0 W: ]2 D! }5 N6 {" H

; W1 _* g( U/ f6 B"A reduction of 87% is definitely more than modest," Elisabetta Rapiti, MD, senior epidemiologist at the Geneva Cancer Registry, tells WebMD in an email interview.6 u/ ^+ Q) B8 d! m- t# u
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The study is published online in the journal Cancer.. ]# d3 Y  S. J  k% J! X$ K1 t
Tamoxifen for Lung Cancer: The Back Story
2 U: r* e/ G# _! M2 TThe finding makes sense in the wake of previous research, Rapiti tells WebMD. In the past, research has found that hormone therapy taken during menopause increases the risk of dying from lung cancer.
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"We have seen in the laboratory that estrogens can stimulate the growth and proliferation of lung cancer cells," she says.9 I; B& \! e4 M5 l: w9 ^" H! c

- l/ a% d4 ~3 a/ A* e! d/ |- z5 x9 lSo, it would follow that the tamoxifen, an “anti-estrogen,” may work against lung cancer.& K# t! Q  t& E: {8 Y5 e1 o
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"Our findings are quite new and exciting, as they are the first to document such a strong association between the use of tamoxifen and reduced mortality of lung cancer," she says.
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The work builds on earlier studies, as far back as the late 1980s, that found evidence that estrogen may be involved in the development of lung cancer, she says, especially adenocarcinomas.
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. M$ ]4 O4 s! U! E+ D) IThe adenocarcinomas occur in smokers and nonsmokers and are more common in women than in men, the American Cancer Society says. The tumors are usually found in the outer region of the lung and account for about 40% of all lung cancers.
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1 A( w# ]* }& eTamoxifen for Lung Cancer: Study Details
2 L- l, g7 `  F. LRapiti's team found that 40 women in the study -- out of a total of 6,655 -- contracted lung cancer during the follow-up, which lasted until December 2007. Although 46% of the women were prescribed tamoxifen or other anti-estrogen drugs to treat their breast cancer, 54% were not.6 }6 f. i8 x' ^
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The researchers looked at which women had been treated with anti-estrogen drugs and didn't find a difference between the groups when it came to getting lung cancer.7 d4 V: }; z" c8 f7 c
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But fewer women with lung cancer on the anti-estrogen drugs died than what would be expected in the general population. They found 87% fewer cases of death from lung cancer in women on the anti-estrogen drugs than in the population at large.+ `1 W- I9 r, C/ X8 A/ t; q$ _

- s& O: q4 \8 M( t: |The women not treated with anti-estrogen drugs had the same risk of dying from lung cancer as other women.
8 |/ f" X5 B& a! H1 l$ s  VThe study finding ''makes sense based on what we have seen in the lab," says Carolyn M. Klinge, PhD, professor of biochemistry and molecular biology at the University of Louisville, who reviewed the study findings for WebMD. She has done basic research in the laboratory on lung cancer cells.2 x' _4 y% Q# Z2 _. `' F5 w1 s

" ?, J! g0 J) SIn her research, she found that lung adenocarcinoma cells sometimes grew when treated with estradiol, a potent natural estrogen, and sometimes did not.
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On looking further, she discovered that the cells that originated from women grew, but those from men did not.
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Tamoxifen for Lung Cancer: The Future* z0 C$ r  B0 |0 m  c$ c: l( q
''The question now is not whether there is an effect [of tamoxifen on lung cancer] but just how big it really is," Rapiti says. * |5 b0 x4 Z- z$ U

( [+ `0 Y' I' D" [4 O, z( y) x. kThe value of tamoxifen for lung cancer treatment will probably be in a select group of patients, she says.) H9 w0 c( s" m2 h, O8 X