主题：诱导多能干细胞来源的人血小板——又向临床迈进一步 ; n% a- `! j; H) W: V8 h内容页：http://jem.rupress.org/content/207/13/2781 & Q+ ]- s" B1 `6 j/ z. C3 a/ w. _* e. w1 U" m0 f
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原文来源自http://jem.rupress.org/content/207/13/2781由干细胞之家新闻小组成员 不倒翁 翻译（转帖请注明）* @8 K) d2 c$ M- M+ |
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2.翻译内容 + S- p8 ]" Z5 z! S7 m5 p0 w/ Q诱导多能干细胞时代的进行是因为它有希望产生无限多的自体细胞应用于再生医学当中。然而，将ips高效的分化为功能齐全的成熟的细胞类型依旧是具有挑战性的。一项新的研究报导，通过最近的努力改进，可以将ips生成功能齐全的血小板，血小板是一种无核的细胞类型，在治疗中的需求量很大。尤其是，这种无核的特性也就使得血小板不能保持ips细胞的多能性和成瘤性。 # D7 i' y3 R& W7 Z$ |2 H% a9 } V, } . T* b% W/ Q8 M% l/ A3.原文: ^1 R" Z% T4 ]4 }5 P
Induced pluripotent stem cell–derived human platelets: one step closer to the clinic+ b; l0 d% {6 ]$ B; W% H5 M
The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of fully functional platelets from human iPS (hiPS) cells improves upon recent efforts to generate this enucleated cell type, which remains in high demand for therapeutic transfusions. Notably, their lack of nucleus renders platelets unable to retain the pluripotent or tumorigenic properties of iPS cells. Y4 b1 @# `( W" v$ |( p: _
; G D# M& N& i! b" F- r4.原文下载连接0 A g6 C3 p# @$ `$ A http://jem.rupress.org/content/207/13/2781 q3 J: j. r3 E+ z+ y/ r1 q# q m) W" i ( n1 p/ i. T: R! l3 B/ n, s5.（选填）本次翻译遇到的难点。有可能希望大家指正的不妥之处。9 O& m: Q+ Q _6 k! d4 B/ G) _1 L; s
还有一篇关于血小板分化的文章，大家可以对比看看：Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells / N p; `9 F5 y" u4 S
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6.注明：个人翻译，理解不准确的语句还望大家积极指出。 2 u1 Y& `, S1 b- D, C作者: 493680468 时间: 2013-2-1 20:06