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gemstone 发表于 2010-5-8 20:41

贡献一篇大牛综述，端粒酶，线粒体，干细胞， 衰老！

[i=s] 本帖最后由 gemstone 于 2010-5-8 20:51 编辑 [/i]

Nature. 2010 Mar 25;464(7288):520-8.

Linking functional decline of telomeres, mitochondria and stem cells during ageing.
Sahin E, Depinho RA.

Belfer Institute for Applied Cancer Science, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract
The study of human genetic disorders and mutant mouse models has provided evidence that genome maintenance mechanisms, DNA damage signalling and metabolic regulation cooperate to drive the ageing process. In particular, age-associated telomere damage, diminution of telomere 'capping' function and associated p53 activation have emerged as prime instigators of a functional decline of tissue stem cells and of mitochondrial dysfunction that adversely affect renewal and bioenergetic support in diverse tissues. Constructing a model of how telomeres, stem cells and mitochondria interact with key molecules governing genome integrity, 'stemness' and metabolism provides a framework for how diverse factors contribute to ageing and age-related disorders.

missyoudad 发表于 2010-5-10 23:45

谢谢分享

missyoudad 发表于 2010-5-10 23:45

谢谢分享

prettyshell 发表于 2010-6-7 13:50

为什么购买了却下载不了呢？

细胞海洋 发表于 2010-6-7 14:09

可以的 再试一次

mihugreen 发表于 2010-6-7 16:12

好文章

ac4072 发表于 2010-7-16 14:55

谢谢

jennyshy 发表于 2010-8-5 14:21

谢谢分享了

天地之间 发表于 2010-11-8 17:13

谢谢了

yonglongh 发表于 2010-11-21 20:25

谢谢分享了 ！！！！！！！！！

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