干细胞之家论坛 › 肿瘤干细胞最新研究快报 › cell上最新的黑色素瘤干细胞文献

hany2007 发表于 2010-6-1 05:09

cell上最新的黑色素瘤干细胞文献

A Temporarily Distinct Subpopulation
of Slow-Cycling Melanoma Cells
Is Required for Continuous Tumor Growth

Melanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population. Isolated JARID1B-positive melanoma cells give rise to a highly proliferative progeny. Knockdown of JARID1B leads to an initial acceleration of tumor growth followed by exhaustion
which suggests that the JARID1B-positive subpopulation is essential for continuous tumor growth. Expression of JARID1B is dynamically regulated and does not follow a hierarchical cancer stem cell model because JARID1B-negative cells can become positive and even single melanoma cells irrespective of selection are tumorigenic. These results suggest a new understanding of melanoma heterogeneity with tumor maintenance as a dynamic process mediated by a temporarily distinct subpopulation.

cyl98 发表于 2010-6-2 23:48

看看。多谢呵

yolanda_sea 发表于 2010-6-20 23:58

多谢啦

xiaostou 发表于 2010-6-23 15:20

感谢楼主

anti1988 发表于 2010-7-1 19:36

kankan

kuangfangnan 发表于 2010-7-12 03:45

thanks for you sharing

wzx6660 发表于 2010-8-5 09:49

thanks for sharing

yanxm920 发表于 2012-10-23 14:08

谢谢楼主

MEMO2012 发表于 2012-12-15 22:05

怎么下载？

sunny雪语 发表于 2014-4-19 16:23

xiexielouzhu

查看完整版本: cell上最新的黑色素瘤干细胞文献