Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent ; l Q4 X% ~# O8 M/ ^: P: p, w; m$ ddifferentiation into fibroblast-like derivative 这是一篇文献的题目，想问问题目中那个telomeric regions 是什么意思
回复 langziforever 的帖子; `# ~/ @9 T5 R1 T' Z4 g
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TERRA, telomeric-repeat-containing RNA : c* C, A7 ~6 W& } i" E/ JTelomeric regions produce TERRA or TelRNA transcripts, which initiate at subtelomeric regions and extend into telomeric sequence, with the telomere leading strand serving as the template for transcription。* |, g. m4 W& ^% u2 K& _4 Y
根据原文，TERRA应该有抑制甲基化或者说去甲基化的作用，我把原文发给你吧
本帖最后由 huangcong1988 于 2011-6-23 21:40 编辑 1 C3 I7 _) @. ]$ M u' O1 `; V3 w
) d7 C2 x; G \回复 殆死悲爱 的帖子: @2 Y' Z* {2 q, L
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是，这篇文章也是讲在重编程过程中，端粒长度改变的，但我有一个疑问，就是该区域能转录翻译吗？端粒在wiki上这样写的：A telomere is a region of repetitive DNA sequence at the end of a chromosome, which protects the end of the chromosome from deterioration or from fusion with neighbouring chromosomes.它既然是一段DNA序列，能转录和翻译吗？
发表于 2011-6-23 15:51
