《细胞-免疫》[Immunity]12年10月18日出版pdf全文

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' M% n" f$ {+ E& {% B& d19 October, 2012 Volume 37, Issue 4
$ }; A' |" j) {% iOn the cover: An immune response can expand rare antigen-specific T cell numbers, but their frequency is subsequently regulated by clonal contraction or deletion. Singh et al. (pages 735–746) have identified a control mechanism by which relatively rare subsets of T cells have “deletor” activity that limits the frequency of antigen-specific T cells but helps maintain the diversity of the repertoire. This regulation involves competition for recognition of endogenous subthreshold ligands (depicted by the purple subterranean sticks) between the deletor cell and the antigen-specific T cell (colored spheres). The presence of deletor cells in different T cell colonies (islands) suggests the peripheral T cell pool is regulated in smaller units. Cover illustration by Alan Hoofring, NIH Medical Art.& Y# R# {+ V, n9 z4 |4 [

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