Oncogene, 2006,25,7663-7672. Embryonic stem cells are characterized by their differentiation to all cell types during embryogenesis. In adult life, different tissues also have somatic stem cells, called adult stem cells, which in specific niches can undergo mul ...
Review. Stem Cell, 2010,28:885-893. Abstract: The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by alternative splicing and alternative translation initiation. OCT4A is a transcription ...
Summary: 1. HIV is a serious but manageable chronic disease that affects persons of reproductive age, many of who express a desire for biologic parenthood. 2. Current treatment of HIV can limit the risk of viral transmission to partner and offspring. Recent studies show that in HIV0infected women, ...
Nature 2007,447:396-398. Geneticists study the gene; however, for epigeneticists , there is no obvious ‘ epigene ’. Nevertheless, during the past years, more than 2500 articles, numerous scientific meetings and a new journ ...
» Article, Nature 2010,463. » Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination o ...
» Review Current Opinion in Biotechnology, 2007,18:467-473. » The recent years have seen great advances in reversal of programming of differentiated somatic cells toward pluripotency bu metods not involving nuclear transfer. Some of these may ...
Embryonic stem cell lines derived from human blastocysts Science, 1998 Human blastocyst -derived, pluripotent cell lines are described that have normal karyotypes , express high levels of telomerase activity, and express cell surface markers that ...
Induced pluripotent stem cell lines derived from human somatic cells Science 2007 Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG, and LIN28) a ...
2007 Cell Induction of pluripotent stem cells from adult human fibroblasts by defined factors Abstract Successful reprogramming of differentiated human somatic cells into a pluripotent ...
Abstract: When the food intake of organisms such as yeast and rodents is reduced (dietary restriction), they live longer than organisms fed a normal diet. A similar effect is seen when the activity of nutrient-sensing pathways is reduced by mutations or chemical inhibitors. In rodents, both dietary ...
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