Nature Method 2009 Immunization of animals and birds for the purpose of developing hyperimmune sera or purification of specific antibodies heavily relies on adjuvants. PickCell laboratories offers a new generation of adjuvants that greatly accelerate development of specific response, decrease the ...
review Insulin resistance is simply the inability of insulin to elicit a physiologic response. While insulin resistance is most commonly associated with the pathogenesis of metabolic disorders such as type II diabetes and obesity, it is also a predisposing factor to a number of other diseases such a ...
Generation of germline-competent induced pluripotent stem cells Nature 2007. Abstract: We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Ocr3/4 (all called Pou5f1), Sox2, c-Myc and Klf4, and su ...
cell 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is kno ...
The Third Evian Annual Reproduction (EVAR) Workshop Group 2008 Background: Recent advances in our understanding of the causes of infertility and of assisted reproductive technology (ART) have led to the development of complex diagnostic tools, prognostic models and treatment options. The Third Ev ...
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts Nature Biotechnology 2008 26: 101-106 Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cel ...
Metabolic syndrome (MetS) represents a combination of cardio-metabolic risk determinants, including central obesity, insulin resistance, glucose intolerance, dyslipidemia, hypertension, hyperinsulinemia, and microalbuminuria. The prevalance of MetS is rapidly increasing worldwide, largely as a conse ...
Human ES cells faces difficulties regarding use of human embryos and rejection following implantation. One way to circumvent these issues is to generate pluripotent cells directly from somatic cells. We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by four f ...
Since the birth of the first " test tube baby " in 1978, more than three million children have been born with the help of reproductive technology. Most of them are healthy. But as a group they're at a higher risk for low birth weight, which is associated with obesity, hypertension and type 2 ...
Dr. Eric S. Rosenberg (Pathology): May we have the medical students'diagnoses? A Harvard Medical Student: The students considered postpartumcardiomyopathy, anthrax, and lymphoma. For the reasons statedby Dr. O'Gara, we considered postpartum cardiomyopathy to be&nbs ...
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