Nature 2007,447:396-398. Geneticists study the gene; however, for epigeneticists , there is no obvious ‘ epigene ’. Nevertheless, during the past years, more than 2500 articles, numerous scientific meetings and a new journ ...
» Article, Nature 2010,463. » Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination o ...
» Review Current Opinion in Biotechnology, 2007,18:467-473. » The recent years have seen great advances in reversal of programming of differentiated somatic cells toward pluripotency bu metods not involving nuclear transfer. Some of these may ...
Embryonic stem cell lines derived from human blastocysts Science, 1998 Human blastocyst -derived, pluripotent cell lines are described that have normal karyotypes , express high levels of telomerase activity, and express cell surface markers that ...
Induced pluripotent stem cell lines derived from human somatic cells Science 2007 Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG, and LIN28) a ...
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