2007 Cell Induction of pluripotent stem cells from adult human fibroblasts by defined factors Abstract Successful reprogramming of differentiated human somatic cells into a pluripotent ...
Abstract: When the food intake of organisms such as yeast and rodents is reduced (dietary restriction), they live longer than organisms fed a normal diet. A similar effect is seen when the activity of nutrient-sensing pathways is reduced by mutations or chemical inhibitors. In rodents, both dietary ...
Nature Method 2009 Immunization of animals and birds for the purpose of developing hyperimmune sera or purification of specific antibodies heavily relies on adjuvants. PickCell laboratories offers a new generation of adjuvants that greatly accelerate development of specific response, decrease the ...
review Insulin resistance is simply the inability of insulin to elicit a physiologic response. While insulin resistance is most commonly associated with the pathogenesis of metabolic disorders such as type II diabetes and obesity, it is also a predisposing factor to a number of other diseases such a ...
Generation of germline-competent induced pluripotent stem cells Nature 2007. Abstract: We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Ocr3/4 (all called Pou5f1), Sox2, c-Myc and Klf4, and su ...
cell 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is kno ...
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