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Glance at last issue:8 U e) R0 `$ Z7 U) N1 q B
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"No stem cells, adult or embryonic, have been induced to secrete enough insulin yet to cure diabetes in humans, but we know spermatogonial stem cells have the potential to do what we want them to do, and we know how to improve their yield...What we are doing is trying to get these cells to think they are in an embryo and they are supposed to make islet cells."--G. Ian Gallicano, Ph.D., an associate professor in the Department of Cell Biology and Director of the Transgenic Core Facility at Georgetown University Medical Center., k, v, d* O) }2 S( R3 k
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“This is the first study to demonstrate that human pluripotent stem cells in a petri dish can be instructed to efficiently form human tissue with three-dimensional architecture and cellular composition remarkably similar to intestinal tissue.”--James Wells, PhD, senior investigator on the study and a researcher in the division of Developmental Biology at Cincinnati Children’s Hospital Medical Center.
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"We use a screening approach to find out which genes are responsible for the reduced function of stem cells. In preliminary investigations, we have identified a gene that activates a protein when DNA or chromosome ends (telomers) are damaged. This particular protein also impedes the proper function of stem cells. We hope to obtain further insights into these processes and subsequently search for a compound that might inhibit the damaging protein and hence enable the regeneration of organ or muscle cells in diseased or elderly patients."--Dr. K. Lenhard Rudolph of University of Ulm.
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# q' S A; ~# N) P+ G8 n“Many cosmetic products use the term ‘stem cell’ loosely. For better accuracy, they should say be ‘stem cell related’ or ‘stem cell‐like effect’ as that’s what they really want to convey to the public.”--Datuk Dr Joginder Singh, director of Health Pathway, a medical centre in Kuala Lumpur focusing on regenerative and aesthetic medicine.4 O3 ?- D; u4 a
9 Q7 s: l% C, i" ^; e“Some lucky ones get positive results but others may experience major complications. I’ve had people bringing their own ‘stem cell concoctions’, asking me to inject them (which of course, I refuse). Some of the products, especially the ones from China (eg. ampules that are supposedly activated upon contact with liquid), have no credibility of source. The integrity of the product is questionable; there is the issue of infection, contamination and you don’t know the technique employed.”--Dr Inderjit Kaur, a doctor and director at Health Pathway.7 {8 x1 {1 [9 y! |6 M
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"Most of the current anti‐cancer therapies used to treat leukaemia attack healthy blood cells as well as cancerous ones. Interestingly, beta‐catenin is not required for normal blood stem cells. So if we can specifically target beta‐catenin in the bone marrow, we can have potentially a more effective and less toxic anti‐leukaemia therapy that can efficiently eradicate leukaemic stem cells but spares healthy blood stem cells."--Professor Eric So of King's College London.
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4 ~2 v$ k4 w" F/ R! M+ d“Never before have we witnessed the rapidity with which findings have been duplicated and incremental advances made to refine a methodology. Today finds any number of investigators worldwide able to direct the reprogramming of somatic cells to pluripotency, using cells obtained from a wide variety of anatomical sources and species, and all manipulated with relative ease. This was an unthinkable task 5 years ago where practitioners of nuclear transfer perhaps stood alone in the hope that such technology might one day be a practical tool to study disease, generate large numbers of defined cell types for use in screening platforms and, that ultimate objective, create patient‐matched cells and tissues for clinical transplantation.”--Regenerative Medicine editors.
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8 C# }# D/ Z: M" |- d, r“Eduardo is edging on, moving ahead a little quicker than some would. However, he is getting things done. There are some basic core scientists who actually see this as a bad thing because they have been trained to understand mechanism. So they don’t think it is valid to move forward to a clinical procedure until you understand mechanism. My argument to them is that if we had said that about diabetes, we never would have started using insulin. We did not understand how insulin worked for 10 years, yet we saved millions of lives long before the discovery that insulin regulates sugar.”--CSRMI Director Clive Svendsen, Ph.D.. f1 Q# A3 t9 o; v$ H
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“Too many have given hESC proponents what they want, rather than giving the public what they need. As a result the latest experiments are moving toward reproductive cloning instead of toward treatments that will actually help patients...The endless quest by these scientists to create pluripotent cells is merely a distraction from advancing proven adult stem cell therapies.”--Dr Theresa Deisher of AVM Biotechnology., S" l3 P! ^: P, }
% ~% U- h! `3 ]( [7 K"It's two sides of the coin: Mechanical force can induce differentiation, and here we said if you can lower the forces between the substrate and the cells, they stay pluripotent. They are complementary processes. Our paper shows that mechanical environment plays at least as important a role as chemical growth factors, if not greater. In vivo, cells produce growth factors for a short time and then they stop. On the other hand, mechanical forces bear on every cell all the time."--mechanical science and engineering professor Ning Wang of University of Illinois.
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This issue:
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Video news:
3 o7 C% X& R {- DChild regains sight after stem cell treatment in China1 x( R6 }# H5 V! ]' i
http://www.telegraph.co.uk/scien ... tment-in-China.html
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9 E# d9 z4 }1 d: JBrain Tumor Breakthroughs Using Stem Cells I* G5 B( c) z
http://www.redorbit.com/news/vid ... ls/33967/index.html
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Stem Cells For ALS: Medicine's Next Big Thing?; b' F3 m, v, I- L
http://www.redorbit.com/news/vid ... ng/34087/index.html |
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发表于 2010-12-22 22:15
