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stem cell news 110317-21 [复制链接]

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楼主
发表于 2011-3-22 22:53 |只看该作者 |倒序浏览 |打印
Glance at last issue:' e9 X8 R& ?4 `( i  a5 n, z9 d
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"It's an exciting time in stem cell biology for a host of reasons. We've entered a whole new phase in the stem cell field, which has been held up enormously by ethical issues for over a decade...It's possible now, of course, to take a few cells from an individual with an intractable disease of some kind for which there are no animal models or any way of studying it, to reprogramme them to an iPS cell state and then differentiate from those the cell type that's affected from the disease. We now have a way of taking them from that person and studying the cell type itself in vitro that will almost certainly have symptoms of the disease. It's possible to produce these models of human disease in vitro which we've never had access to before."--Paul Fairchild, co-director of the newly founded Oxford Stem Cell Institute.
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"In a laboratory dish, pluripotent stem cells promise to become any sort of cell a researcher could want. But when transplanted into the body, such cells could grow unpredictably: clinicians worry most about tumour formation, although one can imagine other dangers, such as tissues growing in the wrong place...Turning knowledge into medicine is never easy. But the pace of knowledge generation itself is fast and furious."--Monya Baker, editor of Nature Reports Stem Cells. 4 ]( ~. m0 {! k7 w7 C

7 L; i7 v6 l+ ]% J"Unlike diagnostic tests that use small sets of biomarkers to examine cells, the molecular model approach uses all of the thousands of pieces of information in a microarray. This results in a diagnostic test with remarkable sensitivity and specificity."--Scripps Research molecular biologist Jeanne Loring.
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“If inventions relating to human embryonic stem cells cannot be patented, investment in Europe by the life sciences industry in this area is likely to dry up with the consequence that new [human embryonic] stem cell-related treatments will not be developed.”--Rob Fitt of the intellectual property lawyers Bristows in London.5 ~- Z' a' Y, N, E& q6 \; L: c

* S' ]" d1 N7 y! p4 s"Up until now, we've been targeting the lower part of the spine and if the therapy was effective -- and that's only if -- what would be retained would be the ability to walk. Walking is not necessarily essential for survival. What is essential for survival is the ability to breathe."--University of Michigan neurologist Eva Feldman.
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"Anytime a research-related tool receives prior clearance from the FDA it has the potential to accelerate the field's move to the clinic and that is CIRM's goal, so this clearance is good news for our mission and good news for patients."-- Alan Trounson, President of the California Institute for Regenerative Medicine.$ O2 c& Q) s- W

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沙发
发表于 2011-3-23 09:06 |只看该作者
本帖最后由 tpwang 于 2011-3-23 09:33 编辑
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回复 kittybruce 的帖子9 C$ y- {2 B* w( n! `0 _" C

0 m9 z/ M2 O  f$ ^这期有几条新闻值得关注一下。
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/ P/ `8 d# K5 X% u% O: ?& J+ \; Z, ]迈阿密大学医学院发表一篇心内注射自体骨髓(单核和间充质)细胞给慢性心肌缺血病患者带来结构和功能改善的结果,与以前类似研究相比,临床指标比较客观,比如瘢痕减小,心脏体积变化,心室功机能改善等。而且这是对长期慢性病理过程的某种“逆转”。据说是一个ongoing randomized clinical trials前期概念性验证。从临床病理机制上提供了比较有力的证据,但细胞和分子水平机制不是该研究的目的,仍有待科学家研究。/ g+ d8 h- L8 R

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约翰霍普金斯医学院发表一篇iPSC精神分裂症基因疾病模型的文章,采用epiosomal vector从精神分裂症病人得到两株带有一个新疾病基因的iPSCs,可以分化为神经细胞如神经元等。据说可以用来模拟和研究一系列精神疾病如schizophrenia, bipolar disorder and major depression等。这里面两个人物是华人,Guo-li Ming和Hongjun Song。 ' V& q  v, N! M1 m  p5 Y
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有篇新闻说麻省白头所(Whitehead Institute)的Jaenisch实验室将在Cell发表一篇iPS文章,说他们新搞的iPS几乎没有基因问题,The DNA of the iPS cells ended up as nearly identical to the DNA of the original skin cells, the researchers said,新闻看不懂到底是什么回事,拭目以待。
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干细胞研究仍旧很热,但最近一系列管理管制规则有不利的消息。欧盟法院对胚胎干细胞产品专利的否决,美国几个周通过法案禁止或限制干细胞研究,说明反对力量还是很强的。! t2 V5 i3 Q3 K/ E& I; I

1 C0 _; P- v, f& D% y一篇与中国有关的新闻。国际干细胞研究协会ISSCR宣布将与苏州工业园合作设立全球干细胞系列论坛。该工业园的会议中心与冷泉港合作成为亚洲会议中心,ISSCR的加入大概是这个合作在干细胞领域的一部分内容。据新闻说10月底开一个500人左右的会,will focus on
; l* |/ J  x  J( e9 X/ bcellular programs and reprogramming。组织者之一邓宏魁教授说:It is important for us to continue building relationships between Chinese and foreign research institutions。顺便说一句,苏州工业园的独墅湖风景不错,会议中心就在湖边(不是广告:)。$ t4 w+ C: v' t  {& `$ g
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藤椅
发表于 2011-3-23 16:16 |只看该作者
学习

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板凳
发表于 2011-3-24 15:57 |只看该作者
干细胞之家微信公众号
I don't like researchers play the role of God. We could explore it but not creat it, at least for the life's own sake.

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发表于 2011-3-28 00:46 |只看该作者
学习了!!
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