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Strongly recommend this "old" paper.
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A Cup Half Empty or Half Full?
6 `$ [& c8 t) _1 Y9 tGeorge Q. Daley
$ @; Q) U: C9 I2 a6 o% y3 \Abstract,6 [. u+ v8 I3 `* `7 m& k$ H# ]
When first reported 4 years ago, gametogenesis from embryonic stem (ES) cells promised an, r8 U6 [4 o! P( E" |/ s3 ]' ^# S
accessible in vitro model to facilitate molecular analysis of the germ lineage. Formation of3 q% M0 {: w: B* X. X& h" t0 u
primordial germ cells is robust, but terminal gametogenesis remains inefficient and doubts
$ S% ~- `- j, E! y# Aabout gamete function persist. Although useful for research, clinical use of ES cell–derived
/ V u( W. z7 d/ S$ f& n& y) Fgametes appears a distant prospect. |
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