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本帖最后由 sunsong7 于 2010-12-30 21:37 编辑
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) n* m5 l" Y3 b* |( H1 {补发图片:“新方法可预测干细胞分化过程”
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* O" u4 x# @' g2 J. p" Z 这是细胞培养实验开始第二天的人体间叶细胞的干细胞免疫荧光图。图中,红色部分为“微柱”,绿色部分为细胞,蓝色部分为细胞核。这个细胞在后期分化为了骨细胞。(图片提供:Michael T. Yang (University of Pennsylvania))" E' z4 g( J% m) r7 p L4 t- [
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$ w |& X" ]3 i; A 这是人体间叶细胞的干细胞扫描电镜图。该细胞被放置在长度为13微米的长“微柱”上生长。在细胞培养实验第二天,细胞产生向心力,这可以从“微柱”的弯曲程度看出。这个细胞在后期分化为了脂肪细胞。(图片提供:Jianping Fu (University of Michigan))' D! z9 }& n& C7 l
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这是人体间叶细胞的干细胞被放置在短“微柱”上培养的扫描电镜图。细胞培养实验第二天,这些细胞开始伸展,其伸展程度和施加在“微柱”上的力均大于在长“微柱”培养的细胞。这些细胞在后期分化为了骨细胞。(图片提供:Jianping Fu (University of Michigan))
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0 S. h- c7 ~* ], SMicromolded elastomeric micropost arrays to engineer substrate rigidity.close
, r3 e* f% Y- f) ^( @% `. p(a) Graphical depiction of finite-element method (FEM) analysis of microposts of heights (L) each bending in response to applied horizontal traction force (F) of 20 nN. (b) Micropost deflection δ is plotted as a function of F, as calculated by FEM an…' d# \5 B0 ~- y4 ]4 n5 a" A
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7 P+ _( g |4 G Quantitative analysis of cell morphology, focal adhesions (FAs) and traction force during rigidity sensing; d4 b# S; d. i, P# L2 V
(a) Distributions of cell area for hMSCs plated on micropost arrays of different rigidities (high rigidity: L = 0.97 μm, K = 1,556 nN μm−1; medium rigiditiy: L = 6.1 μm, K = 18.16 nN μm−1; low rigidity: L = 12.9 μm, K = 1.90 nN μm−1). Gaussian functi… |
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