癌干细胞是正常干细胞癌变产生？？？

marrowstem

       因此可以推测，正常干细胞才是是转化突变的最佳靶细胞，因为干细胞中存在着比成熟细胞多的多的累计突变的机会，那些在时间和空间象限有限的成熟细胞和祖细胞诗达不到这一点的。
+ s6 ~4 o! K- n: U     由此可以认为，具有长久活力的干细胞才是肿瘤发生的真正元凶。干细胞是某些癌症、很可能是所有癌症的致病根源。有些研究人员认为，每一个肿瘤的核心都存在着少数恶变的干细胞，是他们源源不断地产生肿瘤细胞，导致肿瘤增大。

JOEL

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Also highly appreciate this further interpretation thinking creatively.
+ f7 W; P1 v3 DStanding on the shoulders of the masters and the pioneers and being based on the already available information, we can have a picture that it is possible that the first cancerous stem cell in a normal tissue may be produced by ---7 U+ b5 q! b6 [
i), making a normal stem cell of a certain normal tissue to turn into a cancerous stem cell, ---or
; ?3 L, w+ U5 c7 aii), primarily inducing an iPS from a normal somatic cell , then, this "iPS", which has been with the quality of a cancerous stem cell, goes out of control.
! z6 _) n8 e, w2 V/ V( C- \- T1 U# iHowever, no matter from i), or ii), the critical points are still focused on very core of the mechnism of the mutation that is triggered by the interaction between the both key-conditions, i.e. the acquired from the macro-enviroment and the inherited/genetic on/in a normal cell of the organism, i.e. the micro-environment./ @4 F( W! x8 B# E1 J
Persinally, I agree with your reasoning in the model i) from normal stem cell to cancerous stem cell.
$ E3 {" T3 x+ i8 VWe have reached the critical point. Immediately, it calls our hard lab-works to set up the model.
  s7 ^9 m3 d% [3 i: C- LNo doubt, the stem cell research can significantly help us to deepen our understanding on the genesis of the cancerous stem cell via so-called mutation.