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Microtubules get early release

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发表于 2009-3-6 00:18 |显示全部帖子
Some growing MTs (black) get released from the centrosome and sent to the edge of the cell.4 u2 U# h' L1 y4 I# j# L8 E6 Y
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The centrosome is a nucleating center for microtubules (MTs) and the hub of the MT aster. On page 731, Abal et al. report that the centrosome in fibroblasts also seeds a second population of short MTs that are released and transported to the periphery. Both anchored and free MTs are needed for cell migration." S) q6 o% q! _. @

3 F  N# ~- N6 lAbal et al. distinguished the two MT populations using GFP-tagged EB1, a protein that associates with growing MT plus ends. Visualization of EB1 in fibroblasts revealed that one set of MTs moved away from the centrosome toward the cell membrane more rapidly than could be explained by polymerization alone. The speed of this faster group stemmed from active transport of short but growing MTs by the motor dynein. Inhibition of dynein greatly diminished the number of free MTs. Free MTs were also reduced by increasing the centrosomal content of ninein, which anchors astral MTs to the centrosome.
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The transport of free MTs participates in cell migration, as ninein-overexpressing fibroblasts could no longer migrate, but membrane ruffling (regulated by astral MTs) was not affected. Although it is still unclear how MT transport to the leading edge improves cell motility, proteins that break down focal adhesions might piggy-back on the free MTs. Alternatively, the short MTs may be captured by actin fibers to stabilize leading edge lamellipodia.(Some growing MTs (black) get released fr)

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发表于 2015-5-27 11:42 |显示全部帖子
这个贴不错!!!!!看了之后就要回复贴子,呵呵  

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发表于 2015-6-1 10:43 |显示全部帖子
中国干细胞行业门户第一站
鉴定完毕.!  
佰通生物

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发表于 2015-6-1 14:09 |显示全部帖子
干细胞之家微信公众号
我想要`~  

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发表于 2015-7-4 10:18 |显示全部帖子
不对,就是碗是铁的,里边没饭你吃啥去?  

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发表于 2015-7-12 21:34 |显示全部帖子
这个贴好像之前没见过  

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发表于 2015-7-17 18:00 |显示全部帖子
爷爷都是从孙子走过来的。  

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发表于 2015-7-30 17:10 |显示全部帖子
一个有信念者所开发出的力量,大于99个只有兴趣者。  

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发表于 2015-8-15 17:11 |显示全部帖子
文笔流畅,修辞得体,深得魏晋诸朝遗风,更将唐风宋骨发扬得入木三分,能在有生之年看见楼主的这个帖子。实在是我三生之幸啊。  

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发表于 2015-8-28 18:54 |显示全部帖子
怎么就没人拜我为偶像那?? ~  
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