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Mitochondria sensitive to ER Ca2 stores

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发表于 2009-3-6 00:57 |显示全部帖子
The endoplasmic reticulum (ER) converses with mitochondria during apoptosis, as reported on page 1115. The article by Breckenridge et al. identifies Ca21 as an interorganellar signal that sensitizes mitochondria to death-inducing injuries.  G+ C; x, I( V/ }1 n5 H* g6 u

( n' V* v. Z- f* D" j" lThe link between ER-associated events and mitochondrial remodeling during cell death lies in the BAP31 protein, an integral ER membrane protein that is a target of caspase-8. Previous studies indicated that full-length BAP31 inhibits mitochondrial release of cyt c during apoptosis, whereas overexpression of BAP31's caspase cleavage product, p20, induces cell death. The current study demonstrates that p20 exerts its apoptosis-inducing activity from the ER by inducing mitochondrial fission.1 F( C% S% k" ~7 O( S8 j

8 k+ o! G! V3 Q9 B* Z0 e& U0 a1 TER and mitochondria were found to communicate through an exchange of Ca2 . Expression of p20 induced Ca2  release from the ER and near simultaneous Ca2  uptake into the mitochondria. The high mitochondrial Ca2  levels recruited a dynamin- related protein called Drp1, which is known to effect fission. The resulting fragmentation sensitized mitochondria to downstream caspase-8 activities that cause cyt c release. Compared with caspase-8 action alone, the addition of p20 increased cyt c release several fold in vivo. Although isolated mitochondria readily release cyt c in response to caspase signals alone, mitochondria in intact cells may have structural differences that require priming by Drp1 for efficient release of cyt c.(Cleavage of BAP31 causes mitochondria (r)

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发表于 2015-7-18 00:17 |显示全部帖子
原来是这样  

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发表于 2015-9-10 10:18 |显示全部帖子
中国干细胞行业门户第一站
观看中  
佰通生物

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发表于 2015-9-30 19:01 |显示全部帖子
干细胞之家微信公众号
观看中  

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发表于 2015-10-6 14:15 |显示全部帖子
不错,感谢楼主

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发表于 2015-10-7 13:30 |显示全部帖子
说的不错  

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发表于 2015-10-7 20:36 |显示全部帖子
我有家的感觉~~你知道吗  

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发表于 2015-11-5 16:12 |显示全部帖子
好人一生平安  

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发表于 2015-11-14 10:29 |显示全部帖子
不是吧  

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发表于 2015-11-23 09:01 |显示全部帖子
知道了 不错~~~  
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