干细胞之家 - 中国干细胞行业门户第一站

 

 

搜索

点这里关注干细胞之家微信公众号

朗日生物希瑞干细胞
查看: 11807|回复: 79
go

at right angles

Rank: 7Rank: 7Rank: 7

积分
威望
0  
包包
3465  
发表于 2009-3-6 08:23 |显示全部帖子
Bonder/NAS* M0 M, `2 K7 [9 C+ V
$ C0 t: l4 t! u0 R- _. ~" C7 f0 u
A misoriented mitotic spindle may be a short cut to metastasis, based on results from Jurii Vasiliev (Moscow State University, Russia), Edward Bonder (Rutgers University, Newark, NJ), and colleagues.
& K' m8 W) F. e6 L; @
& g, ~( \9 B! i9 `* x* ?' s# DCells in an epithelial layer normally divide perpendicular to their surface; each daughter cell thus remains in contact with the matrix and surrounding cells. The new results show that cells with too much RhoA activity, as found in several cancer cell lines, lost the spindle orientation needed for this perpendicular division. Many of the cells thus made a spindle that left only one daughter on the matrix.
& v: C5 U" i  t5 W5 l9 B0 i) `3 _7 c/ L2 n* P
The other cell, atop its matrix-bound sister, lacked the spread phenotype of matrix-attached cells. Due to inadequate cell–cell adhesions, these rounded cells occasionally detached from the epithelium, floated off in the medium, and settled at new sites.# e9 l: V( `* B& B
8 f/ H$ g3 e2 O' t
Cells with overactive RhoA were more contracted and had altered actin networks suggestive of hyperactive myosin II. Blocking myosin II activity reversed the RhoA effects. Bonder now wonders, "does myosin II activity alter the movement of the formed spindle relative to the cell itself, or is the process of forming the spindle aberrant from the very start?"4 M3 c  [: t) n) [4 y
9 ^  k  T  |/ N/ Z
The results suggest that cancerous cells may not have to acquire the ability to migrate to metastasize. " cell division would lead not only to increased tumor mass," says Bonder, "but could also be squirting out cells." Circulatory flow could then sweep off some of these cells and deposit them elsewhere.' z0 e& X- a1 Z$ j/ Z

; x* G' `6 X! y7 }6 ]Reference:
7 W1 f/ H$ f8 N" Z' y, U4 a% k1 P" R1 o) W- j
Vasiliev, J.M., et al. 2004. Proc. Natl. Acad. Sci. USA. doi:10.1073/pnas.0404723101.(A spindle turned perpendicular (bottom) )

Rank: 2

积分
75 
威望
75  
包包
1548  
发表于 2015-6-24 18:34 |显示全部帖子
谢谢分享  

Rank: 2

积分
98 
威望
98  
包包
1642  
发表于 2015-6-25 22:34 |显示全部帖子
希瑞干细胞
不错不错.,..我喜欢  
佰通生物

Rank: 2

积分
98 
威望
98  
包包
1188  
发表于 2015-6-25 23:35 |显示全部帖子
干细胞之家微信公众号
哎 怎么说那~~  

Rank: 2

积分
162 
威望
162  
包包
1178  
发表于 2015-6-29 21:06 |显示全部帖子
任何的限制,都是从自己的内心开始的。  

Rank: 2

积分
68 
威望
68  
包包
1182  
发表于 2015-7-1 12:19 |显示全部帖子
在线等在线等  

Rank: 2

积分
163 
威望
163  
包包
1282  
发表于 2015-8-1 14:05 |显示全部帖子
干细胞存储  

Rank: 2

积分
66 
威望
66  
包包
1222  
发表于 2015-8-17 17:08 |显示全部帖子
胚胎干细胞

Rank: 2

积分
56 
威望
56  
包包
1284  
发表于 2015-8-26 02:48 |显示全部帖子
对不起,我走错地方了,呵呵  

Rank: 2

积分
72 
威望
72  
包包
1372  
发表于 2015-9-6 18:00 |显示全部帖子
观看中  
你需要登录后才可以回帖 登录 | 注册
验证问答 换一个

Archiver|干细胞之家 ( 吉ICP备13001605号 )

GMT+8, 2018-9-25 20:08

Powered by Discuz! X1.5

© 2001-2010 Comsenz Inc.