张 磊 # i s; O7 y6 Y9 p
(中国科学院上海生命科学研究院生物化学与细胞生物学研究所，上海 200031) ; M9 Z! l& e$ s3 W/ O
# ]: R0 C% @7 k* u' Q9 O8 t摘 要：成体细胞可以通过核移植、细胞融合或者特定因子导入的方式实现重编程回到多能性状态。在重编程的过程中，表观遗传水平的调控机制起到了非常关键的作用。通过回顾重编程的研究进展来探讨表观遗传学在重编程中的调控机制。 . A1 n( \$ Z" D& w2 N; E9 q& t关键词：干细胞；细胞重编程；表观遗传调控；表观遗传学 + S) w, a9 Z& Z) U S! ^中图分类号：Q813；Q75 文献标识码：A : K. H& E" m$ A# }3 h : z/ Z% }6 Z$ L% _) f4 K3 \9 q
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Epigenetic mechanism in cell reprogramming 1 L) U, m* H# t) @! |8 {* I! SZHANG Lei* 4 N2 o/ M- q! ]* |7 z) x. _: D(Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China) 9 t+ R8 Z: Y& l& t
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Abstract: The developmental state of adult cells can be reprogrammed into that of embryonic cells by nuclear transfer, cell fusion or overexpression of specific transcription factors. Epigenetic mechanism plays a key role in the reprogramming. Here we reviewed the research process in reprogramming to explore how epigenetic works in the reprogramming.! F2 n- c; h7 l8 S; v" N+ S- t6 }
Key words: stem cell; cell reprogramming; epigenetic mechanism; epigenetics作者: susanliuxue 时间: 2009-12-13 07:49