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Cell Stem Cell2009年4月3日的一篇文献，希望对大家有帮助 Q! X3 g# r5 z3 N; W1 u+ \4 _% Z
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Cell Stem Cell 4, April 3, 2009
- e* E2 V8 C! g: n: d( eMolecules that Promote or Enhance- z8 N! C/ M2 z: l1 C1 Y' F* [4 T
Reprogramming of Somatic Cells
2 W& q: \3 f: t1 S3 c# kto Induced Pluripotent Stem Cells- Y' j" z) ^3 Y# m, b5 x
Bo Feng,1 Jia-Hui Ng,1 Jian-Chien Dominic Heng,1 and Huck-Hui Ng1,2,*
8 {, A' w- \# E1Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672, Republic of Singapore
1 O, X3 g: Z, K2Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore+ [ Y- z) V$ G0 C' f
*Correspondence: nghh@gis.a-star.edu.sg
# R/ L. f/ R* L: a1 b% w5 V9 L4 @DOI 10.1016/j.stem.2009.03.005
; Y% G+ S* Y/ o, F DReprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated
' _$ B6 V( j& B# w# o- H/ |9 [transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is
* E, c1 t% c9 v1 }! l! E; T, hnecessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to viral& M" ]/ O* d# R t# Z* h
integration. Here, we review recent progress made in the usage of genetic factors, chemical inhibitors,. O, N% ]. o! |& r- D# |* j2 m
and signaling molecules that can either replace core reprogramming factors or enhance reprogramming
' K3 H9 f8 K) e0 v- Q3 X# |& hefficiency. Current iPSC studies will provide a paradigm for the combinatorial use of genetic factors and
4 G+ S- Y' E; J2 bchemicals for the broader applications to alter cellular states of potency.
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abbr_bd5620d537f49c8cee29d8a5f5bfca43.pdf
(292.33 KB)
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发表于 2009-4-27 13:21
发表于 2009-5-6 14:21
