|
- 积分
- 0
- 威望
- 0
- 包包
- 4
|
Cell Stem Cell2009年4月3日的一篇文献，希望对大家有帮助- P1 T7 u6 X) g- ]( {: b
: a0 x+ K& `: O* m) [) p. RCell Stem Cell 4, April 3, 2009* U8 P# l4 a3 V) f5 t2 E
Molecules that Promote or Enhance
1 \/ e0 X4 ^2 w1 L6 @0 yReprogramming of Somatic Cells
; K8 S$ u' Z+ oto Induced Pluripotent Stem Cells& i/ @. k: F* G6 i: e" c
Bo Feng,1 Jia-Hui Ng,1 Jian-Chien Dominic Heng,1 and Huck-Hui Ng1,2,*
6 e4 T/ W* W# b. g. D9 C6 A1Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672, Republic of Singapore. L" S" U( W5 A0 E7 [
2Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore
: p1 ]) \9 A6 a, ], w6 |# Z*Correspondence: nghh@gis.a-star.edu.sg ^% G7 ]+ E4 ~. M6 ?
DOI 10.1016/j.stem.2009.03.005
6 ]; P5 ^. x4 l/ t1 \Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated6 X9 k5 w9 G. y
transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is
- N& H. a& a' ^, Q- X' V1 |( dnecessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to viral6 A- X+ _: I# f6 A
integration. Here, we review recent progress made in the usage of genetic factors, chemical inhibitors,
0 X0 A @0 M. ~- w5 A* Band signaling molecules that can either replace core reprogramming factors or enhance reprogramming
5 y1 [. q( T. fefficiency. Current iPSC studies will provide a paradigm for the combinatorial use of genetic factors and0 {. L/ I3 F- v- Y, I7 z
chemicals for the broader applications to alter cellular states of potency.
6 P4 L' K. ?8 j# o, q, H5 J/ f$ m$ h+ B& h h3 `- M
abbr_bd5620d537f49c8cee29d8a5f5bfca43.pdf
(292.33 KB)
|
|
发表于 2009-4-27 13:21
发表于 2009-5-6 14:21
