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可是这个版本（如果是，我就给你下）：3 Y6 H9 g( H' S; {% f" L
Table of Contents
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& P9 [/ G6 Y) @9 ]I. Principles of Developmental Biology: M4 `; L8 c- ?
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1. Developmental biology: The anatomical tradition
6 U% s5 ?! p/ T& J, XNew techniques of mathematical modeling of development( U- p4 E. W' Q# a' x
2. Life cycles and the evolution of developmental patterns% M. D# a" A6 U. O0 B2 F
Recent advances in planarian regeneration
! N5 ]6 y3 P: n9 B0 v4 P) q3. Principles of experimental embryology& N( ]5 y( a4 }& Z( R/ O; n
4. The genetic core of development' i2 Z# r0 e. q' o
5. The paradigm of differential gene expression
) c; e) ]8 }: H7 w" V: QHistone modifications
9 H! b6 n. Y1 K% [% cMicroRNAs
0 B% g. a2 |) z) SPioneer transcription factors; H+ V9 ~( T) v
Mammalian cloning and methylation patterns) F& _$ o& A3 o& N' W
6. Cell–cell communication in development
9 R' I3 J9 Z, O8 eStem cell specification and stem cell niches5 X1 b; V; _4 K
Morphogenetic regulation by cadherins
& z- e6 ?) A6 e; M5 n& k' yNoncanonical Wnt pathways
( m$ {# N, w# X I: l4 cDependence receptors and apoptosis$ c0 B# B* l, t. T% ^
Community effect and autocrine factors
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: ~9 Q2 k7 \, A1 xII. Early Embryonic Development
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7. Fertilization: Beginning a new organism
% n8 E; K" b6 w/ P+ h# ]Cortical granule components% R# R# y2 y4 d/ D
New mammalian sperm–egg binding model
V4 H7 M$ z, X/ \% f% ?5 j c6 m- s- k4 HMammalian sperm chemotaxis and thermotaxis$ z S* w3 ?1 `: l
Mechanisms of sea urchin sperm chemotaxis
& A4 p7 k9 @8 F$ f7 j- LSea urchin bindin receptor: b1 J+ m8 y( y
Oocyte translation inhibitors and their removal
) j2 @. m& }7 X: A" G3 J$ gNew hypotheses of sperm activation
; }- J$ e# m3 @: n$ NMammalian sperm–egg fusion
; o* g( e9 o5 S9 x8. Early development in selected invertebrates
! s$ L4 z4 N/ rWnt and Nodal in sea urchin axis specification9 G: d8 C& L& p/ @
Coiling genetics of snail embryos
) }: o( s. A1 \Functions of tunicate yellow crescent3 ~8 s( Q3 P( `4 |. z4 ?
Roles of FGFs in tunicate development! R% d9 ?2 W, e0 _
Tunicate heart development
7 b( B& ~" E& Z0 m* J; U9. The genetics of axis specification in Drosophila0 P, ]+ v* f0 {2 D+ S
FGF signals and Drosophila mesoderm formation
6 b E+ a) ~% b8 P* a8 U4 @- zTransport of Nanos and Bicoid messages to opposite ends of the fly oocyte! h/ E0 S- b0 j' B2 a2 e
New model for gap protein stabilization' c; W- n2 A! k: C7 A1 ^
10. Early development and axis formation in amphibians
' n1 l; q% t7 V, K, d# tNew models for organizer formation in Xenopus) e7 j. { l0 Y
New model for mesoderm specification in Xenopus' |) C! d% }+ l7 J
11. The early development of vertebrates: Fish, birds, and mammals4 H1 u' Z. f& K
Maternal effect mutations in zebrafish, b* y9 |+ L! ?& r
Neurulation in zebrafish
* `, Y& d$ @4 Q: rRetinoic acid in anterior–posterior axis specification in chordates' R/ F3 e; K+ S7 V. m& X
Ciliary movements and left–right axis specification in vertebrates
9 Y8 n+ c5 d" T9 ?9 x; xRole of Cerberus in chick head formation, m; [6 [0 p2 }. a' A0 E7 o
Mesoderm specification and migration in chick gastrulae; O4 ?2 t6 J) A0 a3 |
FGF and cell fate in chick and mammalian epiblasts
* J R- X: W5 c' x7 uInduction of pluripotency in mammalian inner cell mass blastomeres% l! p+ m; c, k% k* ~4 Y4 A
Homeotic transformation in mammals due to total Hox paralog knockouts
) M* c9 K' C5 M( YControversy over blastocyst polarity in mammals( i9 j0 `/ _: r4 L8 h
Folate receptors and teratogens affecting neurulation
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, }1 m* _8 f6 X9 g& P# j6 FIII. Later Embryonic Development% }) ]' w1 P& |- J
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12. The emergence of the ectoderm: Central nervous system and epidermis+ x9 S: F: @9 k9 C' i. n
Genes specifying neural fate$ [0 f$ E; u! w
Human-specific genes specifying brain growth
% z2 O7 f6 m& O& H* kProgressive myelination of the human brain
; F, R& o& W7 f- Z% P- \+ F& lNeural stem cells5 A1 Q+ K# n0 d" p. h
Eye development and blind cave salamanders
- L8 _' @2 i. O. F" iSkin, hair, and pigment stem cells
: @" ?9 B6 p& B; f+ h13. Neural crest cells and axonal specificity
( d) |6 g0 f. BNeural crest cell specification and migrations8 G* ~/ y, u1 A; F( Q: C0 W0 p
Head vs. trunk neural crest specification
$ v6 C' ^8 Q' N2 @/ }& z, x9 r# p/ tNeural crest-endoderm interactions forming facial structures( o% Y. R/ `- \
Placode specification and separation5 C. m0 o: c$ J+ ]) \3 W
Tooth development and evolution. J, k& S+ m+ y6 {: |9 v
Semaphorins, Robo, and ephrins in neural patterning
$ l: Z$ L: v1 c2 N14. Paraxial and intermediate mesoderm# d6 M N: S. A; f, t
Specification of paraxial and intermediate mesoderm' X8 g; X; y& x, d3 Z0 x
Epithelialization of somites7 D; y: Q3 I9 y) _4 |' q" R+ N
The syndetome—where tendons arise
5 K5 {2 h7 V* B( S$ |FGFs, Notch, and Wnt in somite specification and separation' y/ S% S' d0 c: P4 D* r+ S2 S7 E
The primaxial and abaxial musculature
4 t0 U$ z% x1 R$ I. O$ K1 ?7 mNew sources of muscle precursor cells7 a _( H0 ?" u6 t& J, P
Pathways of skeleton formation
% o. G' x z: b1 ^# MRegulating ureteric bud branching
) v9 g' o5 @+ x" }8 w0 vWnt and FGF proteins regulating nephron formation
: W F* m5 b+ w* A15. Lateral plate mesoderm and endoderm
& ~2 K! u q: nCloaca formation4 {% [: ~! g. L& D2 J4 f8 H6 n
Heart cell specification
" {6 h; a' X T. D' ?+ V4 ETbx genes, retinoic acid and heart chamber formation) j( j1 R( s m- ~' r
Heart valve development
# i4 S7 }) j6 s& u8 L. ?Hematopoietic stem cells and their derivatives- D' }2 F: _) W- e& a5 Q3 D/ u
Lymphatic development
) M! `* Z" s3 }Induction of arteries by neurons M! d0 t$ a% @/ \( \- a
Placenta as source of blood stem cells
/ c: x. G4 n* e }# ~Adult blood stem cell niches
8 t2 ?' M7 k6 J& gEndoderm specificity/ L2 L, l& t8 K! x
Pancreas vs. liver development- [# m3 c1 B( E3 ?" N* X
Fate mapping pancreatic cells
# L+ u, L; p/ i5 y, |/ U$ r16. Development of the tetrapod limb! [! A& s# N$ Q2 u3 x
Hox code of limb development. a8 f4 F' l# J$ g8 p3 Y' @
Specification of the digits by hedgehog proteins and HoxD genes( I" F8 v) x" n
Controversy over digit identities in dinosaurs and birds. x; b1 J! X- A& e, m* V
Getting limbs from fins0 e4 T- [; C! ]/ e8 D# i' R' p8 Y: m
17. Sex determination
6 m! n% q' W/ _) c$ XTiming and gene expression in mammalian sex determination- P/ J. S, c* y0 e
Brain sex determination pathways in vertebrates and flies6 D1 v; @) [9 w+ F& d5 X' }
Hormone disruptors and sex determination problems
& j& v3 R$ @/ ?8 uDosage compensation and sex determination+ |& v$ [. ^5 `
Temperature-dependent sex determination in turtles* t/ V# J7 ^) E! a7 j2 H% o
18. Metamorphosis, regeneration, and aging
/ n7 y w/ a4 X( H6 y- G" ]Molecular mechanisms of amphibian metamorphosis
/ I k. t* G/ s" | dEcdysone receptors and the response to molting hormone. q7 E& b+ x$ a/ Z! m2 O: y
Compartment formation in the wing imaginal disc
+ h1 k* z G1 PWhy can’t we regenerate our limbs?
3 |% z; T7 j$ `0 \Neuron- and mesenchyme-dependent stages of limb regeneration
8 R5 L1 V/ r6 a9 V1 JSpecification of limb regions by transcription factors during regeneration
& q, w! Y9 ?$ E) O0 i9 l ^Mitochondrial control of aging# {/ _% }$ j# Y5 ]4 [3 r
Insulin pathway control of aging and possible relation to oxygen radicals1 Z+ g9 {# \$ [& P" N
“Ageless” animals and environmental control of aging- p% U/ ^& M' y
19. The saga of the germ line/ k& J+ w. h }1 Q8 W
Genetic specification of germ-line cells in Drosophila and vertebrates
1 ]/ R+ L, }; f$ e/ I+ V% PComponents of the Drosophila germ plasm* h2 ~) [( T+ e# b" ~. U( {
Egg and sperm stem cell niches in Drosophila+ y) A) F' G0 r' O) v
Migration of primordial germ cells in mammals, chicks, and flies
L) u, X- G f2 F# |) f$ W' _6 A4 IDetermination of meiosis and mitosis in C. elegans: x! Z9 N( A* w! D; @+ l6 l
Retaining mammalian spermatic stem cells
$ I/ q9 _+ ^- P2 x% D% xIV. Ramifications of Developmental Biology; i* x' s$ h2 f6 w, R+ |7 E
20. An overview of plant development; l1 L1 g# m& j3 n, U" O2 g# s
Gamete formation and pollen tube guidance* h. Q$ j- M1 o& i$ {- K7 Z
Maternal effects and embryo development
8 s# ]9 i! L* S6 Z& F/ Y* SRadial and axial patterning; p! N" C4 F$ m, c
New model for auxin specification of polarity
3 }9 C. d( g' @; Q' ]Roles of microRNAs in plant development
! o0 F& p8 u) H8 b( l' EDorsal–ventral leaf patterning
6 n) q. N. N3 N {1 yLong-distance RNA transport and flowering w( v, ?% J# z. O* D, x3 S
Floral meristem specification
2 \9 L9 C6 @" Q/ G3 Y2 o0 Y/ L+ v. \; ]21. Medical implications of developmental biology/ M9 E b' r8 U1 k
Mechanisms of alcohol teratogenesis! ]3 e n' Y3 z0 @# n
Effects of endocrine disruptors on human development
+ \2 \5 {2 ~! t9 ?Nutritional effects of gene methylation and disease susceptibility3 e: `& r9 i# `- O+ H* q1 b
Cancer as a disease of development9 o+ w" c4 y+ C& Z; U+ v: @
Cancer stem cell hypothesis
+ X& n+ M1 [0 P5 ] }7 bDevelopmental approaches to cancer therapy
9 G. n. J& V5 G. J% W9 o1 {: eStem cell therapeutics6 t3 K' D! s7 e$ |) L
Regenerating human limbs and neurons. @- [3 G$ J2 z* O2 N; D
22. Environmental regulation of animal development5 t7 ` h5 a6 A0 \
Molecular bases for environmental regulation of gene expression
; b$ l v/ j% }/ [• Importance of symbionts in mammalian gut and immune system. ], G1 g# [# }* Q& o I/ H
development
1 w4 h8 Z; [1 y* G# F4 Z6 Y$ {Signaling from fetal mammalian lung to initiate labor
9 A: G# l3 ^& c) K& K4 z7 EThe role of nutrition in the development of the dung beetle4 t ^8 R# d( U0 N s7 i6 o
Predator-induced polyphenism and toxicity testing- J i" W5 x, u5 Q$ X. }( N i2 m
Genetic assimilation of environmentally induced traits9 [4 z* _7 x" N2 h Q) F
23. Developmental mechanisms of evolutionary change, A/ d: v0 i* U8 I ^% D
Developmental modularity and evolution (stickleback studies)
7 S8 I8 C5 A8 [; YEvolution by heterochrony, heterotopy, heterometry, heterotypy+ Q% A( _3 R" ]: o. z. [% g1 F
BMPs and Darwin’s finches
% L/ _+ I0 u: X! r! lOrigin of neural crest cells and the origin of jaws% w! g" m, W% ^% \4 ^
The search for the Urbilaterian ancestor |
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发表于 2009-7-10 21:51
