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本帖最后由 细胞海洋 于 2009-8-3 14:51 编辑 ( N3 h5 ^$ {. t3 B8 }0 A
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Stem Cells：精原干细胞可直接诱导为各种终端细胞
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3 g3 Z; \) _2 h' V1 N; H& _Stem Cells. 2009 Apr 16;27(7):1666-1675.
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Direct Transdifferentiation of Stem/Progenitor Spermatogonia Into Reproductive and Nonreproductive Tissues of All Germ Layers.6 r9 y6 O. z8 W S# X2 W9 Q
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Simon L, Ekman GC, Kostereva N, Zhang Z, Hess RA, Hofmann MC, Cooke PS.1 i# b% O& G4 o# N/ k
Department of Veterinary Biosciences,University of Illinois, Urbana, Illinois, USA.
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Pluripotent stem cells have great clinical potential for tissue regeneration/repair in humans. The use of embryonic stem (ES) cells is ethically controversial, leading to searches for other sources of pluripotent stem cells. Testicular spermatogonial stem cells (SSCs) produce the spermatogenic lineage. Under in vitro conditions, SSCs have the ability to give rise to pluripotent ES-like cells. We hypothesized that stem/progenitor spermatogonia could directly transdifferentiate into different tissue types if they were recombined with inductive mesenchymes from fetal/neonatal organs using a tissue separation/recombination methodology and grown in vivo. Green fluorescent protein transgenic mice were used to track cell lineages. Our results indicate that stem/progenitor spermatogonia recombined with the appropriate mesenchyme can directly transdifferentiate in vivo into tissues of all germ layers, including prostatic, uterine, and skin epithelium. In addition, transdifferentiated tissue expressed molecular, histological, and functional markers of the appropriate epithelium. The ability of stem/progenitor spermatogonia to directly generate various epithelia emphasizes their clinical potential, and if adult human SSCs have similar properties, this may have applications in human regenerative medicine. STEM CELLS 2009;27:1666-1675.
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PMID: 19544441 |
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发表于 2009-7-30 12:59
发表于 2009-7-30 17:00
