PDF电子书《Epigenetics》C. David Allis 冷泉港出版社 2007 表观遗传学圣经

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Epigenetics' Q6 J8 F9 e& o* P4 k6 d
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Edited By C. David Allis, The Rockefeller University, New York;
* I, _3 ]8 b; A5 `9 m) U7 k  T& |& IThomas Jenuwein, Research Institute of Molecular Pathology, Vienna;
' |3 k8 }2 E* {4 S4 ]6 IDanny Reinberg, Howard Hughes Medical Institute/University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School;& J1 g7 H* ^' Q0 u) x% `
Marie-Laure Caparros, Associate Editor 4 A1 |: E7 c* d* j6 d

+ I4 ]' E+ n6 ~" A% ?Description, r# f/ ?! z9 g5 F9 e

2 p( X+ k& i: c! VThe regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.
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# f9 p/ B8 f& D1 m% G. ]Contents
7 T+ q- s: B0 g! ]+ o1. Epigenetics: From Phenomenon to Field% W$ P/ c& a2 q8 Y9 W7 J# y
D.E. Gottschling
1 V/ B9 v2 S! z% Y# X! i3 b2. A Brief History of Epigenetics' N( w2 S2 F1 l/ j' H$ W* J
G. Felsenfeld
3 t2 o: _) k. u7 v3. Overview and Concepts
  k& e9 D, N+ g# |) n( sC.D. Allis, T. Jenuwein, and D. Reinberg
! @9 U5 T2 ]/ \. s6 d3 ]  T! ~4. Epigenetics in Saccharomyces cerevisiae
" p2 L6 b3 w9 ], S$ HM. Grunstein and S. Gasser
& y! g* L3 k( F9 B5. Position Effect Variegation, Heterochro-matin Formation, and Gene Silencing in Drosophila! A% D) W4 ^2 C* O: ~- f
S.C.R. Elgin and G. Reuter
% }7 P  A% M4 c3 y6. Fungal Models for Epigenetic Research: Schizosaccharomyces pombe and Neurospora crassa0 O0 b2 K) B" ]& G8 C+ T
R.C. Allshire and E.U. Selker
8 ?1 h1 o/ G9 @! ]7. Epigenetics of Ciliates
7 Y7 b: Q8 O; U  w& NE. Meyer and D.L. Chalker( b+ T+ {0 [2 y# U- f; X
8. RNAi and Heterochromatin Assembly7 @: J+ j+ t: k, O/ D
R. Martienssen and D. Moazed) M; }5 ^6 P0 c- r
9. Epigenetic Regulation in Plants
2 r& X0 H8 O* v  G9 ]6 s$ X$ RM. Matzke and O. Mittelsten Scheid
" A- j$ \$ g7 Z) y10. Chromatin Modifications and Their Mechanism of Action
( O5 O: y7 ]$ i+ x- u3 \T. Kouzarides and S.L. Berger* ^$ _& A' S5 u$ S5 `
11. Transcriptional Silencing by Polycomb Group Proteins3 Y7 M2 z  n; J2 g- j. t
U. Grossniklaus and R. Paro; y& C4 i) E' L  V9 p
12. Transcriptional Regulation by Trithorax Group Proteins- Q* b! k; J2 ]7 A3 K/ Q. N
R.E. Kingston and J.W. Tamkun- f9 ~. m# {, @
13. Histone Variants and Epigenetics
* |+ L2 Q6 H+ ]3 @S. Henikoff and M.M. Smith
% A+ x. {2 I1 X  ?8 d- G% I3 {14. Epigenetic Regulation of Chromosome Inheritance4 [- q' P9 D0 C* W0 w- h
G.H. Karpen and R.S. Hawley, y5 |6 t, {3 W7 ~8 p6 d! C
15. Epigenetic Regulation of the X Chromosomes in C. elegans
5 H1 s  r5 v, c5 B9 u+ MS. Strome and W.G. Kelly
& V8 n2 \0 L) O) Q+ W. Z16. Dosage Compensation in Drosophila
# u( M. O4 P7 Z% RJ.C. Lucchesi and M.I. Kuroda9 d4 c+ |+ X& x3 F: s
17. Dosage Compensation in Mammals( l( z! K/ v! k4 R- {0 G' }$ Q1 R
N. Brockdorff and B.M. Turner
' _: s1 C' K6 X4 V( F0 G6 H18. DNA Methylation in Mammals+ J5 x* G( q' Y2 }! ]# v/ N
E. Li and A. Bird
4 X* h0 i6 D- G; U$ O2 |! `19. Genomic Imprinting in Mammals
. C# H  ~  J+ ]D.P. Barlow and M.S. Bartolomei4 r6 t" }7 h, ~# V/ b  {& x$ D; f5 g
20. Germ Line and Pluripotent Stem Cells
+ d. Z! a" L& ^. \. w; w) o" N, {M.A. Surani and W. Reik  n6 n1 F- `: x
21. Epigenetic Control of Lymphopoiesis' T) u6 w0 x- {6 h6 V8 G
M. Busslinger and A. Tarakhovsky
5 l# G9 N) [7 k- b! U; x3 b) J22. Nuclear Transplantation and the Reprogramming of the Genome
' S4 i" Q, C( Q# v% w$ kR. Jaenisch and J. Gurdon1 U; n( N) X8 D( y, T/ o* R( |& p
23. Epigenetics and Human Disease3 Y' ?) n' Z0 r
H.Y. Zoghbi and A.L. Beaudet
3 ]1 X$ t4 m+ U( y0 F+ u24. Epigenetic Determinants of Cancer
0 H; Z# j; I  qS.B. Baylin and P.A. Jones# y8 S  G  M8 H$ h* n' B# e
Appendices3 e3 J7 w4 ]% d6 o
Index' S# ]+ H* r) b( Z) p

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hualin840518

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感谢

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