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本帖最后由 细胞海洋 于 2010-1-25 00:13 编辑
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FOREWORD
3 c) ^5 ~. c# NStem cell biology is emerging as a field in biology with tremendous therapeutic potential.( B! Z* H l, @) `3 h
Making this potential a reality requires an international effort. The recognition
3 G2 u2 y6 _5 C& ^6 }0 Othat such a promising yet multifaceted discipline needs fostering led to the establishment( t, k) {( U* y& q0 H& L
of the International Society for Stem Cell Research (ISSCR). Central to the efforts of the
$ c3 A% L8 Q& Q! q$ L \5 S* R0 \( c' H( VISSCR is the development of tools to ensure the success of stem cell researchers. What& @; G& K3 Y7 n3 P
better way to do this than to collaborate with Current Protocols to develop this valuable
8 \$ {" h1 s2 l) V) V1 G8 zcompendium of protocols in stem cell biology?0 m2 F+ k* E \" z* K6 ?* R
Stem cell researchers have developed a number of breakthrough techniques, from the( ^2 [# n# W* x) G! E8 @7 J4 w
derivation and manipulation of pluripotent embryonic stem cells to purification and8 f+ R# H9 l9 q2 x/ b
transplantation of tissue-restricted stem cells from adult organs. A number of laboratories
6 z4 w! h3 s; ]" @7 C& Rhave become leaders in the field as a result of developing such techniques. The more, S4 Q0 W, S. ~- Z
efficient scientists are at implementing new and powerful methodologies in their own4 _1 G* E3 n6 x0 R. C
laboratories, the faster stem cell biology will advance our understanding of normal4 L: a3 v2 c) a8 A' U# Y
development and lead to the development of therapies. Thus, the availability of quality
. u) j# _- A4 D5 d* M9 ~protocols will have amajor impact on the success of the entire field. Current Protocols has3 r6 H' U g; p
long been the premier volume for proven in-depth protocols regarding many aspects of0 F: y4 U k& E
biology, and this volume on stem cell biology will prove a valuable addition to researchers" ]$ ]: A# y2 f" H( a
worldwide.
: f6 l h9 {$ C" NExperiments in stem cell biology must be interpreted with great caution as well as
/ s0 Z6 ]$ t0 }) V7 H: L( nopenness to alternative explanations. For example, the recently discovered phenomenon
( D0 r2 p1 z8 x" }of cell fusion in vivo or the existence of tissue-restricted blood stem cells in peripheral& D, \. |/ E, d( X( K2 ~, F
tissues were initially misinterpreted as evidence for stem cell trans-differentiation.6 }. ]5 l+ b+ X7 Z( c) e
It is very important that this compendium of protocols highlight potential pitfalls as well
( l' d5 P6 P5 J7 Bas maintain the opportunity for clarification and correction when the need arises. The
6 V0 n3 u2 _. P+ B0 J$ t2 _fact that these protocols will be provided online will help ensure that researchers always# { D& N/ h# P, m6 W% C
have the latest, most up-to-date protocols available to them.
, \6 D7 [/ u& a0 \. @8 y+ K) [( hThe stem cell field is burgeoning, and, as I have seen within the ISSCR, there is a genuine
2 z: z$ f E# ~! U9 x q3 a( ?% |push to share information and interact so that the field can move forward quickly. There: n- l# f2 N: B( o6 @+ n
is a drive to develop not only excellent basic research skills but to bring the findings
) i7 j' H* g' {3 Q; A, Q* N: O; w$ }# ~( Eto clinical use so that patients can benefit. As a Hematology Attending Physician at
7 j2 F* l- O/ ?+ uChildren’s HospitalBoston, I treat children who have pediatric blood diseases or leukemia
0 v `/ h" h2 M2 ^and am drawn by the need to translate our research findings into therapies to help treat a
9 m1 C" ^8 ~4 }/ q! Wnumber of diseases. The promise is great, but we need to deliver, and I believe Current
" q3 J! W" ^+ q' W# l+ m3 ?) sProtocols in Stem Cell Biology will help tremendously.9 a5 [- ~- j8 n. y: g6 c
Leonard I. Zon% d8 M( e& n# G! u% E7 }
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发表于 2010-1-24 23:41
发表于 2010-5-7 15:38
