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本帖最后由 细胞海洋 于 2010-1-25 00:13 编辑 4 s1 v' M) Y* T4 B5 K" r# c9 D
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FOREWORD# d; e0 g8 A4 B5 U$ l; y
Stem cell biology is emerging as a field in biology with tremendous therapeutic potential.! ^& K- r: a8 @2 G. z7 O
Making this potential a reality requires an international effort. The recognition2 z9 a+ b$ x3 X$ ?$ U$ I5 y
that such a promising yet multifaceted discipline needs fostering led to the establishment
1 U4 E( A6 C) D, o7 wof the International Society for Stem Cell Research (ISSCR). Central to the efforts of the+ O! ~2 J% v6 k5 L7 b9 q J w
ISSCR is the development of tools to ensure the success of stem cell researchers. What3 S% w3 m( n9 q8 a" A
better way to do this than to collaborate with Current Protocols to develop this valuable
7 c" n4 p1 U, }1 @compendium of protocols in stem cell biology?( P1 }8 W" b, X7 z' F/ _2 G! n
Stem cell researchers have developed a number of breakthrough techniques, from the
9 q3 Q; p, r3 M( l- ?6 U/ b+ S, ?derivation and manipulation of pluripotent embryonic stem cells to purification and
5 ]. h2 Z$ G" O# P/ atransplantation of tissue-restricted stem cells from adult organs. A number of laboratories& Q) v, G& I, W1 P* d
have become leaders in the field as a result of developing such techniques. The more1 _' v( Z8 L! K$ R/ l
efficient scientists are at implementing new and powerful methodologies in their own0 C4 i3 R" j( L f+ u. U* Y2 v7 R
laboratories, the faster stem cell biology will advance our understanding of normal
$ n# c4 e3 p7 gdevelopment and lead to the development of therapies. Thus, the availability of quality$ H2 L$ Z# [5 L
protocols will have amajor impact on the success of the entire field. Current Protocols has
9 M# U. v6 e) x+ G, [; Z; @; \, ]& dlong been the premier volume for proven in-depth protocols regarding many aspects of
- W! M$ A( @5 |* r% nbiology, and this volume on stem cell biology will prove a valuable addition to researchers* ?% e. I( [& S' s5 Q: Q
worldwide.5 M; B+ Q! h# X, V3 q, ~0 B
Experiments in stem cell biology must be interpreted with great caution as well as& t3 M: b3 {% A0 T. P
openness to alternative explanations. For example, the recently discovered phenomenon- d8 M2 \/ w$ T. S- X0 A) ?: W
of cell fusion in vivo or the existence of tissue-restricted blood stem cells in peripheral+ z4 g( u7 @! a7 p6 F1 K7 p
tissues were initially misinterpreted as evidence for stem cell trans-differentiation./ x2 E! `0 K3 B6 j% R! a& A6 m
It is very important that this compendium of protocols highlight potential pitfalls as well6 E( w) P8 O3 M* }$ Y8 T
as maintain the opportunity for clarification and correction when the need arises. The
6 u. q1 b8 M Q" l( ^0 M3 }fact that these protocols will be provided online will help ensure that researchers always
- S; P& K, l% H8 q' Z% o0 T4 v2 Yhave the latest, most up-to-date protocols available to them.
7 i* J; Z: O/ ~' n4 XThe stem cell field is burgeoning, and, as I have seen within the ISSCR, there is a genuine
" K: S |7 _0 c( S* C; Vpush to share information and interact so that the field can move forward quickly. There
, ^" ~" Q1 K. `& y; Tis a drive to develop not only excellent basic research skills but to bring the findings
$ _" S* D# w4 K& z7 m( s- Q. [to clinical use so that patients can benefit. As a Hematology Attending Physician at- A. a% P& I, N4 D
Children’s HospitalBoston, I treat children who have pediatric blood diseases or leukemia7 W# N" ]& T# g" J- t
and am drawn by the need to translate our research findings into therapies to help treat a+ w1 e9 E; s, [: Y& b
number of diseases. The promise is great, but we need to deliver, and I believe Current' ^2 \6 O! ^( `
Protocols in Stem Cell Biology will help tremendously.
/ \( t% N1 ?# @' M3 c( \2 RLeonard I. Zon
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发表于 2010-1-24 23:41
发表于 2010-5-7 15:38
