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本帖最后由 细胞海洋 于 2010-1-25 00:13 编辑 + J& C6 l# ?' U5 |) m
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FOREWORD' c$ R9 N" ]8 P
Stem cell biology is emerging as a field in biology with tremendous therapeutic potential.$ M6 s2 }. I3 x0 ]! V* p5 n. M' ?: ?
Making this potential a reality requires an international effort. The recognition! u' {, L2 K( _. Y+ w6 F* b2 D( w
that such a promising yet multifaceted discipline needs fostering led to the establishment
2 w' b7 _9 _$ kof the International Society for Stem Cell Research (ISSCR). Central to the efforts of the
* s' |1 q; t; c+ u M3 v) oISSCR is the development of tools to ensure the success of stem cell researchers. What
/ z( o# {. `$ ?: v% H: L0 Xbetter way to do this than to collaborate with Current Protocols to develop this valuable1 ]4 x2 \* Y: n- p" @
compendium of protocols in stem cell biology?
& o. F6 j. k# m5 @/ mStem cell researchers have developed a number of breakthrough techniques, from the, r. G$ h# x3 R: x: ]+ y
derivation and manipulation of pluripotent embryonic stem cells to purification and* a- m( K/ a5 m( }6 [0 e( k2 U
transplantation of tissue-restricted stem cells from adult organs. A number of laboratories
; o8 }5 F$ U# i: k: I2 W. I- k# vhave become leaders in the field as a result of developing such techniques. The more3 e0 E% H9 G( K) [: @
efficient scientists are at implementing new and powerful methodologies in their own( e* t4 _# @8 B8 r6 Q
laboratories, the faster stem cell biology will advance our understanding of normal! K' |( }# Q; O* Y
development and lead to the development of therapies. Thus, the availability of quality
2 k2 M% [. w9 o2 N4 x8 y: rprotocols will have amajor impact on the success of the entire field. Current Protocols has
4 d' k& ^3 Q% B) @+ tlong been the premier volume for proven in-depth protocols regarding many aspects of) m3 y5 H6 |+ Q7 R! q* n7 d' Y) T
biology, and this volume on stem cell biology will prove a valuable addition to researchers; Z& k+ V3 q8 g) K6 a, q
worldwide.% C b& l4 I% Q& t- M. K
Experiments in stem cell biology must be interpreted with great caution as well as' O7 v% O# e5 x9 h, x" w" U
openness to alternative explanations. For example, the recently discovered phenomenon1 A+ f" ^' L; F+ g
of cell fusion in vivo or the existence of tissue-restricted blood stem cells in peripheral' z9 S: _/ j( h) O
tissues were initially misinterpreted as evidence for stem cell trans-differentiation.
' Y$ Q, R$ h: A% ]It is very important that this compendium of protocols highlight potential pitfalls as well
( V# X* X% ~" ?& @. _# Xas maintain the opportunity for clarification and correction when the need arises. The! @; I9 N% u) I2 o7 y0 b* J! M
fact that these protocols will be provided online will help ensure that researchers always
0 u$ g, K9 u0 ~( ?! M0 y, hhave the latest, most up-to-date protocols available to them.+ }9 Q, N3 X, g- i7 M/ [3 ?" h
The stem cell field is burgeoning, and, as I have seen within the ISSCR, there is a genuine. }* E. S3 i3 O2 |; f/ J( m
push to share information and interact so that the field can move forward quickly. There
$ z, D+ _& P- v, l A$ P4 O9 a' Vis a drive to develop not only excellent basic research skills but to bring the findings
1 I, E1 u0 c& J! o; Oto clinical use so that patients can benefit. As a Hematology Attending Physician at: P" J5 I" Y0 {+ V1 d, @0 [- l6 `5 k
Children’s HospitalBoston, I treat children who have pediatric blood diseases or leukemia7 v. [6 O( s0 B5 ?. w
and am drawn by the need to translate our research findings into therapies to help treat a( B- L8 v9 u1 c# d* w% f" Z& X
number of diseases. The promise is great, but we need to deliver, and I believe Current
5 N7 U3 ]. |" C8 x! t3 AProtocols in Stem Cell Biology will help tremendously.
4 a4 B8 c; l* ]- @0 B- lLeonard I. Zon3 F3 ?( c; Y9 N& E! l# o5 \
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发表于 2010-1-24 23:41
发表于 2010-5-7 15:38
