一篇关于肿瘤转移的新想法，似乎涉及肿瘤干细胞

天天快乐

今天看到一篇文章，关于肿瘤转移的新想法，似乎涉及肿瘤干细胞，有兴趣的可以讨论一下这篇文章的观点是否有问题？
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Metastasis: Inherent vs. acquired phenotype.2 H1 c5 ]9 j+ y, V5 r9 {- M
Zhang LJ, Li H, Zhang LY, Gu Y, Song Y, Li F, Jiang LN, Li Q, Zhang HZ, Zhang F.
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Department of Clinical Laboratory, Tangdu Hospital, Shaanxi 710033, PR China.
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The problem how tumor cells get the metastatic ability is still a hot debate. Based on the premise that the default state of normal cells is quiescent rather than mobile, the classic progression and early metastasis model suggested that tumor metastasis should be an acquired trait contributed by the late or early gene mutations during carcinogenesis. Here, an inherent metastasis model is proposed that the metastatic ability of the tumor cells is one of the constitutive features of the normal cells of tumor origin. The idea is based on two facts. One is that tumor arises from stem or progenitor cells and in turn are driven by tumor stem cells. The other is that emerging evidence showing that a small population of stem or progenitor cells has the inherent migration capacity in normal development and adulthood. This inherent metastatic model has some implications. First, metastatic dissemination should occur continually throughout the course of primary tumor development and generate a diverse spectrum of disseminated cells. Second, most of the disseminated tumor cells should have the stem cell like features. Third, migration of stem cells and cancer cells should invoke similar molecular processes involving metastasis. Fourth, genomic alterations that primarily promote the production of tumor cells with stem cell traits, i.e., tumor stem cell, exacerbate tumor progression and metastasis. Finally, overt metastatic production is primarily determined by whether the disseminated tumor cells can survive and grow into overt metastatic foci at the ectopic sites, instead of that whether the tumor cells can leave the primary sites and travel to other sites. All these predictions have gotten increasing supporting evidences. Yet, to confirm whether the new paradigm is true or false, it needs carefully examine whether normal stem or progenitor cells of various tissues have the potential to traveling and arriving at the ectopic sites. Furthermore, exploiting the mechanisms for regulating normal stem or progenitor cells migration may provide more critical results for our deeply understanding the secrets of tumor metastasis and offer new methods for preventing and treating tumor metastasis. Copyright © 2009 Elsevier Ltd. All rights reserved.7 K& E; K; n' o* [
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PMID: 20006450 [PubMed - as supplied by publisher]

饶冠华

回复 1# 天天快乐 全文

饶冠华

文章提到的观点很有道理。至于为什么所有的肿瘤到最后都能发生转移？这个是需要重新思考的问题。有两种可能：1.本身就具备的性质。2.后天获得的性质（通过突变之类的）。但要根据概率来算，第二种可能就似乎小得多。

prettybear

干细胞具有迁移的能力，肿瘤干细胞具有干细胞的特征，在他存在的哪一天可能就赋予了转移的能力。个人推测：在肿瘤初期可能肿瘤干细胞虽然具有这种能力，但外部条件并不容许，因为肿瘤的转移还涉及到其他条件；到后期肿瘤强大了能够制造这些条件，能够发生转移。但肿瘤干细胞的这种干细胞特征是如何来的并不知道？

wzx6660

学习谢谢

hcoohboy

干细胞具有迁移的能力，肿瘤干细胞具有干细胞的特征，在他存在的哪一天可能就赋予了转移的能力。个人推测： ...% g0 ]. W4 Z0 ^0 O
prettybear 发表于 2010-3-18 13:12

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    我看过一篇很牛的nature review cancer综述就是这个观点

hcoohboy

还是推荐多看牛人写的review，MH要以批判的眼光看~~~

饶冠华

我看过一篇很牛的nature review cancer综述就是这个观点
; [8 z, z( x' {1 K5 }4 ~hcoohboy 发表于 2010-3-25 10:01

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有全文的话，建议发上来大家学习一下哈

hcoohboy

有全文的话，建议发上来大家学习一下哈+ U  x8 I9 j& V) e) r
饶冠华 发表于 2010-3-25 10:27

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7 j$ L" u! {  \1 @; f- d! ^' y    就是这篇

prettybear

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  }$ d/ c/ z) R1 Q    我还以为是自己乱想呢。非常想拜读这篇文章，以下载，非常感激提供这篇文章。