美国杜克大学医学中心确认多效生长因子可促进造血干细胞再生（附原文）

细胞海洋

3 F+ z3 P6 R# O# c8 q. O2 _- `' m4 }' b3 z/ z/ S. V; D% _
新华网华盛顿３月２１日电（记者任海军）美国杜克大学医学中心科学家日前通过实验确认，多效生长因子可促进造血干细胞扩张和再生。这项成果在再生医学领域具有广阔应用前景。
9 P% |' |$ @6 O: S
  R+ y1 G8 X+ w$ X6 M9 n2 O    有关论文已发表在新一期英国《自然·医学》杂志上。研究人员在论文中表示，对需要干细胞移植的患者而言，脐带血是普遍的造血干细胞来源，但脐带血中的干细胞数量通常比较有限，因此开发出能快速促进脐带血干细胞生长的方法就尤为重要。
# h6 u- d  V  Z0 }1 v0 m' Q) L. }; [$ _/ k) ^2 h
    研究人员将多效生长因子注入骨髓生长因受到辐射而被抑制的实验鼠体内，后者的骨髓干细胞生长速度与未注射多效生长因子的实验鼠相比提高了１０倍。在实验室培养皿中，多效生长因子还被确认可促进人类脐带血干细胞的生长。研究人员还证实，多效生长因子不会导致实验鼠出现癌变。 , Z3 H6 c  X$ ?& ^

  p$ w" s" W" z/ h    研究人员说，这项成果将来有望使更广泛的人群受益于脐带血移植，更重要的是，对正在接受化疗或放疗的患者而言，利用多效生长因子进行的治疗或许具有加速患者血液和免疫系统恢复的潜力。不过他们也表示，在利用这项成果进行临床治疗前，还需要进行更多动物实验。
$ C; ~) Z. S- {2 a  ^. t, V
* m3 m6 {& Y# n+ [* n9 z8 _6 D5 w0 F    研究人员目前正在进一步开展实验，以验证多效生长因子是否也对普通干细胞的生长和发展至关重要。# Z6 q, E1 o0 I$ ?6 s% u! V$ A

( j* {* m3 i/ @4楼原文 感谢realinter 提供

cdcliwei

Well done!

ambassador

' c; j( ~9 G. @2 x
' T( X/ B# n0 c% M& A! z  x
多效生长因子简介：
& R0 o' {; K% hPleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1), also known as PTN, is a well conserved gene.' w8 z$ t1 C) I; V0 W

9 C8 g0 {9 r( i8 PPleiotrophin or Neurite Growth-promoting Factor 1 (NEGF1), also called Heparin Affin Regulatory Peptide (HARP) or Heparin Binding Growth associated molecule (HB-GAM) is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.
& }6 h0 |% F+ U& N/ w+ ~
( ?. M9 i% @4 U+ I  Q5 ]$ f  {0 Y" WPleiotrophin was initially recognized as a neurite outgrowth-promoting factor present in rat brain around birth and as a mitogen toward fibroblasts isolated from bovine uterus tissue. Together with midkine these growth-factors constitute a family of (developmentally regulated) secreted heparin-binding proteins now known as the Neurite Growth-promoting Factor (NEGF) family. During embryonic and early postnatal development, pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin is also expressed by several tumor cells and is thought to be involved in tumor angiogenesis. In the adult central nervous system Pleiotrophin is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. Pleiotrophin expression is low in other areas of the adult brain, but it can be induced by ischemic insults. or targeted neuronal damaged in the enthorrinal cortex or in the Substantia Nigra pars compacta.4 t" E5 I8 {) |$ H: f

+ [4 Y% T9 x1 Ofrom：http://en.wikipedia.org/wiki/Pleiotrophin

realinter

不错的文章，贴出来与大家共享。

slong

看看

ssyt

这篇文章有点意思~~

saberly

kankan

chenmay

谢谢